Composite particles which contain both cellulose and inorganic compound

Patent metadata

Field	Value
Publication number	US-9446137-B2
Application number	US-201514591514-A
Country	US
Kind code	B2
Filing date	Jan 7, 2015
Priority date	Jun 29, 2010
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

Provided are composite particles which exhibit excellent fluidity and high liquid retentivity and which exhibit high fluidity even in a liquid-holding state. Also provided are composite particles which permit direct compressing in an open feed manner and which suffer from little compressing trouble and exhibit high shapability. When shaped together with an active ingredient, the composite particles provide shaped bodies which have uniform weight, uniform active ingredient content, and high hardness and which suffer from less galling.

First claim

The invention claimed is:

1. Composite particles comprising a cellulose and an inorganic compound, wherein an apparent specific volume of the composite particles is 7 to 13 cm 3 /g, and a volume average particle size of the cellulose as a water-dispersed cellulose is 10 to 40 μm.

2. The composite particles according to claim 1 , comprising 10 to 60 parts by mass of the cellulose and 40 to 90 parts by mass of the inorganic compound.

3. The composite particles according to claim 1 , wherein the inorganic compound is at least one selected from the group consisting of silicon dioxide hydrate, light anhydrous silicic acid, synthetic aluminum silicate, magnesium hydroxide-aluminum hydroxide co-precipitate, magnesium aluminometasilicate, magnesium aluminosilicate, calcium silicate, non-crystalline silicon oxide hydrate, magnesium silicate, and magnesium silicate hydrate.

4. The composite particles according to claim 1 , wherein the inorganic compound is calcium silicate.

5. The composite particles according to claim 1 , wherein a pore size of the composite particles is 0.003 to 1 μm, and a pore volume of the composite particles is 1.9 to 3.9 cm 3 /g.

6. The composite particles according to claim 1 , wherein a retention rate for the composite particles of tocopherol acetate is 500 to 1000%.

7. The composite particles according to claim 1 , wherein a weight average particle size of the composite particles is 30 to 250 μm.

8. The composite particles according to claim 1 , further comprising starch.

9. A molded article comprising the composite particles according to claim 1 and an active ingredient.

10. The molded article according to claim 9 , wherein the active ingredient is an ingredient for a medicament or an ingredient for health food.

11. A molded article comprising composite particles comprising a cellulose and an inorganic compound, wherein an apparent specific volume of the composite particles is 7 to 13 cm 3 /g, and a volume average particle size of the cellulose as a water-dispersed cellulose is 10 to 40 μm, and an active ingredient, wherein the active ingredient is a liquid having a viscosity at 25° C. of 3 to 10000 mPa·s, and the molded article contains 105 to 250 mg of the active ingredient per 500 mg of one molded article.

12. The molded article according to claim 11 , wherein the active liquid ingredient is tocopherol acetate.

Assignees

• Asahi Kasei Chemicals Corp

Inventors

• Magome Takumi
• Obae Kazuhiro

Classifications

• A61K9/2054 Primary

  Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose · CPC title

• A61K47/02

  Inorganic compounds · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• Y10T428/2991

  Coated · CPC title

• Y10T428/2998

  including synthetic resin or polymer · CPC title