Method of manufacturing solid dosage form

Patent metadata

Field	Value
Publication number	US-9445971-B2
Application number	US-201313804229-A
Country	US
Kind code	B2
Filing date	Mar 14, 2013
Priority date	May 1, 2012
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

In one aspect, the present invention features a method of manufacturing a solid dosage form, the method including the steps of: (a) measuring an amount of a first powder blend within a dosing nozzle, wherein the first powder blend includes a pharmaceutically active agent; (b) discharging the measured amount of a first powder blend from the dosing nozzle into a forming cavity within a die block, the forming cavity having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (c) moving a first forming tool into the forming cavity through the first opening of the forming cavity such that the first powder blend is formed into the shape of the dosage form within the forming cavity between the inner wall, the first forming tool and a second forming tool within or adjacent to the cavity; (d) applying RF energy between a first electrode and a second electrode such that the energy heats the first powder blend within the forming cavity to form the dosage form; and (e) removing the dosage form from the forming cavity.

First claim

What is claimed is:

1. A method of manufacturing a solid dosage form, said method comprising the steps of:
(a) measuring an amount of a first powder blend within a dosing nozzle, wherein said first powder blend comprises a pharmaceutically active agent;
(b) discharging said measured amount of a first powder blend from said dosing nozzle into a forming cavity within a die block to obtain a volume of powder blend comprising at least said first powder blend within said forming cavity, said forming cavity having an inner wall, a first opening at the surface of one side of said die block, and a second opening at the surface on the opposite side of said die block;
(c) moving a first forming tool into said forming cavity through the first opening of said forming cavity such that said volume of powder blend comprising at least said first powder blend is formed into the shape of said dosage form within said forming cavity between said inner wall, said first forming tool and a second forming tool within or adjacent to said cavity;
(d) applying RF energy between a first electrode and a second electrode such that said energy heats said first powder blend within said forming cavity to form said dosage form; and
(e) removing said dosage form from said forming cavity.

2. A method of claim 1 , wherein said measured amount of said first powder blend is delivered to said dosing nozzle using negative pressure.

3. A method of claim 1 , wherein said measured amount of said first powder blend is discharged from said dosing nozzle using positive pressure.

4. A method of claim 2 , wherein said measured amount of said first powder blend is discharged from said dosing nozzle using positive pressure.

5. A method of claim 1 , wherein said first powder blend has a density of less than 0.5 g/cc.

6. The method of claim 1 , wherein said RF energy is applied at a frequency from about 1 MHz to about 50 MHz.

7. The method of claim 1 , wherein said first RF electrode is operably associated with said first forming tool, said second RF electrode is operably associated with said second forming tool, and the portion of the inner wall of said forming cavity which is adapted to form said dosage form is insulative to said RF energy.

8. The method of claim 1 , wherein one of said forming tools removes said dosage form from said forming cavity.

9. The method of claim 1 , wherein said dosage form is placed into a blister card upon said removal from said forming cavity.

10. A method of manufacturing a solid dosage form, said method comprising the steps of:
(a) measuring an amount of a first powder blend within a first dosing nozzle wherein said first powder blend comprises a pharmaceutically active agent;
(b) discharging said measured amount of said first powder blend from said first dosing nozzle into a forming cavity within a die block to obtain a volume of powder blend comprising at least said first powder blend within said forming cavity, said forming cavity having an inner wall, a first opening at the surface of one side of said die block, and a second opening at the surface on the opposite side of said die block;
(c) measuring an amount of a second powder blend within a second dosing nozzle;
(d) discharging said measured amount of a second powder blend from said dosing nozzle into said forming cavity block to obtain a volume of powder blend comprising at least said first powder blend and said second powder blend within said forming cavity;
(e) moving a first forming tool into said forming cavity through the first opening of said forming cavity such that said volume of powder blend comprising at least said first powder blend and said second powder blend are formed into the shape of said dosage form within said forming cavity between said inner wall, said first forming tool and a second forming tool within or adjacent to said cavity;
(f) applying RF energy between a first electrode and a second electrode such that said energy heats at least said first powder blend within said forming cavity to form said dosage form; and
(g) removing said dosage form from said forming cavity.

11. A method of claim 10 , wherein said measured amount of said first powder blend is delivered to said first dosing nozzle using negative pressure and said measured amount of said second powder blend is delivered to said second dosing nozzle using negative pressure.

12. A method of claim 10 , wherein said measured amount of said first powder blend is discharged from said dosing nozzle using positive pressure and said measured amount of said second powder blend is discharged from said second dosing nozzle using positive pressure.

13. A method of claim 11 , wherein said measured amount of said first powder blend is discharged from said dosing nozzle using positive pressure and said measured amount of said second powder blend is discharged from said second dosing nozzle using positive pressure.

14. A method of claim 10 , wherein said first powder blend has a density of less than 0.5 g/cc.

15. The method of claim 10 , wherein said RF energy is applied at a frequency from about 1 MHz to about 50 MHz.

16. The method of claim 10 , wherein said first RF electrode is operably associated with said first forming tool, said second RF electrode is operably associated with said second forming tool, and the portion of the inner wall of said forming cavity which is adapted to form said dosage form is insulative to said RF energy.

17. The method of claim 10 , wherein one of said forming tools removes said dosage form from said forming cavity.

18. The method of claim 10 , wherein said dosage form is placed into a blister card upon said removal from said forming cavity.

19. The method of claim 10 , wherein said first powder blend and said second powder blend are added simultaneously to said forming cavity.

20. A method of manufacturing a solid dosage form, said method comprising the steps of:
(a) measuring an amount of a first powder blend within a first dosing nozzle wherein said first powder blend comprises a pharmaceutically active agent;
(b) discharging said measured amount of said first powder blend from said first dosing nozzle into a forming cavity within a die block, said forming cavity having an inner wall, a first opening at the surface of one side of said die block, and a second opening at the surface on the opposite side of said die block, wherein said forming chamber further comprises a movable divider adapted to form said first chamber and a second chamber within said forming cavity and said first powder blend is discharged into said first chamber;
(c) measuring an amount of a second powder blend within a second dosing nozzle;
(d) discharging said measured amount of said second powder blend from said dosing nozzle into said second chamber;
(e) removing said movable divider from within said forming cavity such that said first powder blend contacts said second powder blend within said forming cavity;
(f) moving a first forming tool into said forming cavity through the first opening of said forming cavity such that said first powder blend and said second powder blend are formed into the shape of said dosage form within said forming cavity between said inner wall, said first forming tool and a second forming tool within or adjacent to said cavity;
(g) applying RF energy between said first electrode and said second electrode such that said energy heats said first powder blend within said forming cavity to form said dosage form; and
(h) removing said dosage form from said forming cavity

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Anderson Oliver
• Sowden Harry S
• Mcnally Gerard P
• Stuhl William J

Classifications

• A61K9/2086

  Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat (active cores with a complete drug-free outer coat A61K9/28) · CPC title

• A61K31/137

  Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone} · CPC title

• A61K31/167

  having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol · CPC title

• A61K9/2095

  Tabletting processes · CPC title

• A61K9/2072

  characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms (A61K9/0004, A61K9/0056, A61K9/0065 take precedence) · CPC title