Drug eluting insert for implantable body

Patent metadata

Field	Value
Publication number	US-9440009-B2
Application number	US-201313767061-A
Country	US
Kind code	B2
Filing date	Feb 14, 2013
Priority date	Feb 16, 2012
Publication date	Sep 13, 2016
Grant date	Sep 13, 2016

Abstract

The present application discloses embodiments related to an implant and a method of forming an implant configured to treat a fractured bone. The implant can include a body having a proximal end, a distal end, and an outer surface extending from the proximal end to the distal end, wherein the body defines a central axis extending from the proximal end to the distal end; and a high tensile strand positioned adjacent the body such that at least a portion of the strand extends at least partially along the outer surface of the body in a direction substantially parallel with the central axis, and wherein the strand is loaded with an active agent.

First claim

What is claimed:

1. An implant comprising:
a body having a proximal end, a distal end, an outer surface extending from the proximal end to the distal end, and an inner surface that defines a cannula, wherein the body defines a central axis extending from the proximal end to the distal end, and wherein the cannula extends in a direction coaxial with the central axis along at least a portion of the implant;
a high tensile strand positioned adjacent the body such that at least a portion of the strand extends at least partially along the outer surface of the body in a direction substantially parallel with the central axis, wherein the strand is at least partially disposed within the cannula of the body, and wherein the strand is loaded with an active agent;
a cap that is received at least partially within the cannula when the body is implanted, wherein the cap receives the strand near the distal end of the body; and,
a ring member including an inner surface that defines a bore, the bore sized and shaped to slidably receive the outer surface of the body such that the body and the ring member can translate with respect to one another in a direction substantially parallel to the central axis.

2. The implant of claim 1 , wherein the cap defines a longitudinal bore that is configured to receive a guidance member that aids in implantation of the implant.

3. The implant of claim 1 , wherein the ring member secures the strand relative to the outer surface of the body such that the strand is spaced apart radially along at least a portion of the outer surface of the body.

4. The implant of claim 3 , wherein as the body is implanted into a medullary cavity of a bone, at least a portion of the strand is in contact with both the outer surface of the body and the bone.

5. The implant of claim 1 , wherein the body further defines at least one aperture, the at least one aperture extending from the outer surface into the body such that the at least one aperture is angularly offset with the central axis.

6. The implant of claim 5 , wherein the strand is at least partially disposed within the aperture.

7. The implant of claim 1 , wherein the strand is biodegradable.

8. The implant of claim 1 , wherein the strand further includes a coating layer.

9. The implant of claim 8 , wherein the active agent is disposed as particles within the coating layer.

10. The implant of claim 8 , wherein the active agent is dissolved within the coating layer.

11. The implant of claim 1 , wherein the active agent is dissolved within the strand.

12. The implant of claim 1 , wherein the active agent is disposed as particles within the strand.

13. The implant of claim 1 , wherein the strand includes a monofilament.

14. The implant of claim 1 , wherein the strand includes a multifilament.

15. The implant of claim 1 , wherein the strand includes at least one ribbon.

16. The implant of claim 1 , wherein the active agent includes at least one antibiotic.

17. The implant of claim 16 , wherein the at least one antibiotic includes gentamicin.

18. The implant of claim 1 , wherein the body is configured as a bone plate.

19. The implant of claim 1 , wherein the body is configured as an intramedullary nail.

20. A method of forming an implant having an active agent comprising:
attaching a high tensile strand containing an active agent strand to an insertion tool;
advancing the insertion tool through a cannula of an implantable body from a proximal end of the implantable body to a distal end of the implantable body in a direction coaxial with a central axis of the implantable body, wherein the body includes a cap that is affixed to the distal end of the body when the body is implanted;
detaching the strand from the insertion tool; and
affixing the strand to the cap;
wherein the implantable body defines a central axis extending from the proximal end to the distal end and has an outer surface extending from the proximal end to the distal end, an inner surface that defines a cannula extending in a direction coaxial with the central axis along at least a portion of the implantable body from the proximal end to the distal end; and
wherein at least a portion of the affixed strand extends along a portion of the outer surface of the body in a direction substantially parallel with the central axis and is at least partially disposed within the cannula of the body.

21. The method of claim 20 , wherein at least a portion of the strand is affixed to the implantable body such that the strand is spaced apart radially along the outer surface.

22. The method of claim 20 , wherein the cap is disposed at least partially within the cannula.

23. The method of claim 22 , wherein the cap defines a bore such that when the cap is at least partially disposed within the cannula, the bore is configured to receive a guidance member that aids in implantation of the implant.

24. The method of claim 22 , wherein at least a portion of the strand is affixed to the implantable body such that the strand is spaced apart radially along the outer surface.

25. A drug delivery system comprising:
an implantable body having a first end, a second end, an outer surface extending from the first end to the second end, and an inner surface that defines a cannula, wherein the body defines a central axis extending from the first end to the second end, and wherein the cannula extends in a direction coaxial with the central axis along at least a portion of the implantable body from the proximal end to the distal end; and,
a strand retention mechanism including a cap and a ring member, wherein the cap is configured to be affixed to the first end of the implantable body and the ring member is configured to be removably securable to the outer surface of the implantable body such that the ring is slidable along the outer surface of the body; and
a plurality of high tensile strands configured to be affixed to the cap and removably securable to the ring member, wherein the strands are secured to the ring member such that the strands are spaced apart from one another radially about the ring member, and wherein the strands are loaded with an active agent, and further wherein at least one high tensile strand is at least partially disposed within the cannula of the body.

26. The system of claim 25 , wherein the plurality of strands are removably securable to the ring member such that the at least a portion of the plurality of strands are spaced apart from the outer surface of the implantable body.

27. The system of claim 25 , wherein the plurality of strands are spaced apart from one another radially along the outer surface of the body in regular intervals.

28. A drug delivery system comprising:
a strand retention mechanism including a cap and a ring member, wherein the cap is configured to be affixed to a first end of an implantable body and the ring member is configured to be removably securable to an outer surface of the implantable body such that the ring is slidable along the outer surface of the body;
a plurality of high tensile strands configured to be affixed to the cap and removably securable to the ring member, wherein the strands are secured to the ring member such that the strands are spaced apart from one another radially about the ring member, and wherein the strands are loaded with an active agent; and,
an insertion tool that is configured to receive the

Assignees

• Depuy Synthes Products Inc

Inventors

• Armbruster David
• Adlon Katlin
• Chomyn Jeffrey
• Yu aaron

Classifications

• A61B17/72 Primary

  Intramedullary devices, e.g. pins or nails · CPC title

• A61B2017/00004

  (bio)absorbable, (bio)resorbable or resorptive · CPC title

• A61B17/80

  Cortical plates {, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates} · CPC title

• A61F2002/30677

  Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title