Reinforced absorbable multilayered hemostatis wound dressing

Patent metadata

Field	Value
Publication number	US-9439997-B2
Application number	US-40084906-A
Country	US
Kind code	B2
Filing date	Apr 10, 2006
Priority date	Oct 20, 2004
Publication date	Sep 13, 2016
Grant date	Sep 13, 2016

Abstract

The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.

First claim

We claim:

1. A hemostatic multilayered wound dressing comprising a first carrier layer with thrombin and fibrinogen, each is in the form as a dispersed powder, wherein the first carrier layer is an absorbable nonwoven fabric having a basis weight of about 0.01 to 0.2 g/in 2 that comprises glycolide/lactide copolymer and a staple fiber having a length from about 1.0 to 1.3 inches that is derived from fiber of about 1 to 4 denier per filament, and one or more second absorbable woven or knitted fabric having a basis weight of about 0.001 to 0.2 g/in 2 that comprises oxidized regenerated cellulose that reinforces the first carrier layer and is separate from the dispersed powders, wherein the multilayered dressing has a basis weight of about 0.1 to 1.0 g/in 2 , wherein the first absorbable nonwoven fabric comprises from about 70 to 95% by molar basis of polyglycolide and the remainder polylactide.

2. The multilayered dressing of claim 1 , where the staple fiber is crimped.

3. The multilayered dressing of claim 1 , wherein the thrombin activity on the multilayered dressing ranges from about 20 to 500 IU/cm 2 , and the fibrinogen amount on the multilayered dressing ranges from about 2 to 15 mg/cm 2 .

4. A hemostatic multilayered dressing comprising a first carrier layer with thrombin and fibrinogen, each is in the form as a dispersed powder, wherein the first carrier layer is an absorbable nonwoven fabric comprising glycolide/lactide copolymer and a staple fiber having a length from about 0.75 to 1.5 inch, a second absorbable woven or knitted fabric that is a reinforcing layer attached to the first carrier layer and is separate from the dispersed powders comprising oxidized regenerated cellulose, wherein the glycolide/lactide copolymer comprises from about 70 to 95% by molar basis of polyglycolide and the reminder polylactide, the thrombin activity on the multilayered dressing ranges from about 20 to 500 IU/cm 2 , the fibrinogen amount on the multilayered dressing ranges from about 2 to 15 mg/cm 2 .

5. The multilayered wound dressing according to claim 3 , wherein the dressing is sterilized.

6. The multilayered wound dressing according to claim 4 , wherein the dressing is sterilized.

7. A hemostatic multilayered wound dressing comprising a first absorbable nonwoven fabric and thrombin and fibrinogen as dispersed powders; one or more second absorbable woven or knitted fabric that comprises oxidized regenerated cellulose.

8. A hemostatic multilayered wound dressing as set forth in claim 1 or 4 wherein the fibrinogen amount is between 5-10 mg/cm 2 .

9. A hemostatic multilayered wound dressing as set forth in claim 1 or 4 wherein the weight ratio of the fibrinogen to the carrier and reinforcing layers is in the range of 0.26:1 to 0.52:1.

Assignees

• Gorman Anne Jessica
• Pendharkar Sanyog Manohar
• Zhang Guanghui
• Bar Liliana
• Nur Israel
• Meidler Roberto
• Ethicon Inc
• Omrix Biopharmaceutical Inc

Inventors

• Gorman Anne Jessica
• Pendharkar Sanyog Manohar
• Zhang Guanghui
• Bar Liliana
• Nur Israel
• Meidler Roberto

Classifications

• B32B2262/06

  Vegetal fibres · CPC title

• B32B2262/062

  Cellulose fibres, e.g. cotton · CPC title

• A61L2300/608

  having two or more layers · CPC title

• A61L2400/04

  Materials for stopping bleeding · CPC title

• Y10T442/2525

  Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.] · CPC title