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Macrocycles
US9439984B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9439984-B2 |
| Application number | US-201314403401-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 14, 2013 |
| Priority date | May 31, 2012 |
| Publication date | Sep 13, 2016 |
| Grant date | Sep 13, 2016 |
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- Title
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Abstract
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The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
First claim
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We claim: 1. A macrocycle having the structure: wherein A p1 and A p2 are independently selected from wherein R s comprises a solubilizing group; and R 11 is methyl or ethyl; and each n is an integer independently selected from 2 and 3. 2. The macrocycle according to claim 1 , wherein A p1 and A p2 are each 3. The macrocycle according to claim 2 , having a structure selected from 4. A complex comprising a macrocycle according to any one of the preceding claims and a metal ion. 5. The complex according to claim 4 , wherein said metal is a radionuclide. 6. The complex according to claim 5 , wherein said radionuclide is Thorium (Th). 7. The complex according to claim 5 , wherein said radionuclide is Cerium (Ce).
Assignees
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Classifications
Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium · CPC title
- A61K51/0482Primary
chelates from cyclic ligands, e.g. DOTA · CPC title
Antineoplastic agents · CPC title
containing three or more hetero rings · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
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Frequently asked questions
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- What does patent US9439984B2 cover?
- The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
- Who is the assignee on this patent?
- Univ California
- What technology area does this patent fall under?
- Primary CPC classification A61K51/0482. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 13 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).