Composition

Patent metadata

Field	Value
Publication number	US-9439837-B2
Application number	US-201113878399-A
Country	US
Kind code	B2
Filing date	Oct 10, 2011
Priority date	Oct 8, 2010
Publication date	Sep 13, 2016
Grant date	Sep 13, 2016

Abstract

The present invention relates to a photosensitive composition comprising synthetic nanocrystalline hydroxyapatite or a synthetic precursor thereof doped with a rare earth ion, the use of the composition in restorative or cosmetic dentistry, a process for preparing the composition and a method of generating an image of an exposed dentinal surface of a tooth.

First claim

The invention claimed is:

1. A photosensitive composition, comprising:
i. synthetic nanocrystalline hydroxyapatite doped with each of (a) a rare earth ion, (b) an aluminum ion, and (c) a fluoride ion;
ii. monetite; and
iii. brushite.

2. The photosensitive composition as claimed in claim 1 , wherein the rare earth ion exhibits absorption bands which substantially match or overlap one or more absorption bands of the synthetic nanocrystalline hydroxyapatite.

3. The photosensitive composition as claimed in claim 1 , wherein the rare earth ion is an erbium, ytterbium, holmium or thulium ion.

4. An aqueous, ketonic or alcoholic dispersion of a photosensitive composition as claimed in claim 1 .

5. The photosensitive composition as defined in claim 1 for use in restorative or cosmetic dentistry.

6. A solid form of the photosensitive composition as defined in claim 1 .

7. A process for preparing a photosensitive composition comprising:
(a) preparing an aqueous mixture of calcium, phosphate, fluoride, aluminum, and rare earth ions at a pH in the range 5 to 14;
(b) mixing the aqueous mixture to form photosensitive composition comprising:
i. synthetic nanocrystalline hydroxyapatite doped with each of (a) the rare earth ion (b) the aluminum ion, and (c) the fluoride ions;
ii. monetite; and
iii. brushite;

(c) isolating the photosensitive composition.

8. A cosmetic method for whitening or veneering a tooth of a human or non-human animal subject comprising:
(1) applying an amount of a photosensitive composition as defined in claim 1 to a surface of the tooth other than a dentinal surface; and
(2) irradiating the amount of the photosensitive composition with laser irradiation so as to promote densification.

9. A method for generating an image of an exposed dentinal surface of a tooth of a human or non-human animal subject comprising:
(A) administering an amount of a photosensitive composition as defined in claim 1 to the exposed dentinal surface;
(B) irradiating the photosensitive composition or physiologically tolerable formulation thereof with irradiation;
(C) capturing the radiation emitted by the photosensitive composition or physiologically tolerable formulation thereof; and
(D) generating from the radiation emitted by the photosensitive composition or physiologically tolerable formulation thereof an image of the exposed dentinal surface.

Assignees

• Sibbett Wilson
• Brown Christian Thomas Alcuin
• Jha Animesh
• Milne Steven John
• Robinson Colin
• Duggal Mandeep Singh
• Toumba Kyriacos Jack
• Univ Leeds Innovations Ltd
• The Univ Court Of The Univ Of St Andrews

Inventors

• Sibbett Wilson
• Brown Christian Thomas Alcuin
• Jha Animesh
• Milne Steven John
• Robinson Colin
• Duggal Mandeep Singh
• Toumba Kyriacos Jack

Classifications

• A61K6/20 Primary

  Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish · CPC title

• A61K6/17 Primary

  Particle size · CPC title

• A61K6/838

  Phosphorus compounds, e.g. apatite · CPC title

• A61K6/842

  Rare earth metals · CPC title

• A61K6/75

  Apatite · CPC title