Speed change algorithm for a continuous flow blood pump

Patent metadata

Field	Value
Publication number	US-9433714-B2
Application number	US-201314405948-A
Country	US
Kind code	B2
Filing date	Jun 6, 2013
Priority date	Jun 6, 2012
Publication date	Sep 6, 2016
Grant date	Sep 6, 2016

Abstract

A ventricular assist device (“VAD”) includes a continuous-flow pump ( 2 ) implantable in fluid communication with a ventricle (V) and an artery (A) of a patient to assist blood flow from the ventricle to the artery. The VAD also includes a control circuit ( 12 ) connected to the pump, the control circuit being configured to direct the pump to operate in a series of cycles. Each cycle may include (i) pumping blood at a first speed (RPM 1 ) and at a first flow rate during a first period (t 1 ); then (ii) decreasing the speed of the pump from the first speed to a second speed (RPM 2 ) during a ramp-down period (t RD ); then (iii) pumping blood at the second speed and at a second flow rate during a second period (t 2 ); and then (iv) increasing the speed of the pump from the second speed to the first speed during a ramp-up period (t RU ).

First claim

The invention claimed is:

1. A ventricular assist device comprising:
a continuous-flow pump implantable in fluid communication with a ventricle and an artery of a patient to assist blood flow from the ventricle to the artery;
a control circuit connected to the pump, the control circuit being configured to direct the pump to operate in a series of cycles, each cycle including:
(i) pumping blood at a first speed and at a first flow rate during a first period; then
(ii) decreasing the speed of the pump from the first speed to a second speed during a ramp-down period; then
(iii) pumping blood at the second speed and at a second flow rate during a second period; and then
(iv) increasing the speed of the pump from the second speed to the first speed during a ramp-up period,
wherein the second speed is a function of the first speed, the second speed is selected so that pressure within the ventricle during systole occurring during the second period momentarily exceeds pressure within the artery thereby opening a native aortic valve between the ventricle and the artery, and the second flow rate is a net positive antegrade flow;
wherein the first speed of each cycle is substantially the same as the first speed of every other cycle, and the second speed of each cycle is substantially the same as the second speed of every other cycle.

2. The ventricular assist device of claim 1 , wherein the second speed is a linear function of the first speed.

3. The ventricular assist device of claim 2 , wherein the second speed is between about 75% and about 90% of the first speed.

4. The ventricular assist device of claim 1 , wherein the first period is between about 5 seconds and about 30 seconds.

5. The ventricular assist device of claim 4 , wherein the ramp-down period, the second period, and the ramp-up period total about 5 seconds.

6. The ventricular assist device of claim 5 , wherein the second speed is about 80% of the first speed.

7. The ventricular assist device of claim 5 , wherein the second speed is about 85% of the first speed.

8. The ventricular assist device of claim 1 , wherein the ramp-down period, the second period, and the ramp-up period total between about 4 seconds and about 10 seconds.

9. The ventricular assist device of claim 1 , wherein the control circuit includes a processor and a memory connected to the processor, the processor being operative to command the pump responsive to instructions stored in the memory, the memory having stored therein:
(i) a first preset operating profile in which the first period is about 10 seconds, the ramp-down period, the second period, and the ramp-up period total about 5 seconds, and the second speed is about 80% of the first speed,
(ii) a second preset operating profile in which the first period is about 10 seconds, the ramp-down period, the second period, and the ramp-up period total about 5 seconds, and the second speed is about 85% of the first speed, and
(ill) a third preset operating profile in which the first period is about 30 seconds, the ramp-down period, the second period, and the ramp-up period total about 5 seconds, and the second speed is about 85% of the first speed.

10. The ventricular assist device of claim 1 , wherein the first flow rate is no more than 3 liters per minute greater than the second flow rate.

11. A method of operating a ventricular assist device incorporating a continuous flow pump connected between an artery and a ventricle of a patient comprising the steps of cyclically:
(i) pumping blood from the ventricle to the artery of the patient by operating a continuous flow pump at a first speed and at a first flow rate during a first period; then
(ii) decreasing the speed of the pump from the first speed to a second speed during a ramp-down period; then
(iii) pumping blood from the ventricle to the artery by operating the pump at the second speed and at a second flow rate less than the first flow rate during a second period; and then
(iv) increasing the speed of the pump from the second speed to the first speed during a ramp-up period,
wherein the second speed is selected so that pressure within the ventricle during systole occurring during the second period momentarily exceeds pressure within the artery thereby opening a native aortic valve between the ventricle and the artery, but so that the second flow rate is a net positive antegrade flow;
wherein the first speed of each cycle is substantially the same as the first speed of every other cycle, and the second speed of each cycle is substantially the same as the second speed of every other cycle.

12. The method of claim 11 , wherein the second speed is a linear function of the first speed.

13. The method of claim 12 , wherein the second speed is between about 75% and about 90% of the first speed.

14. The method of claim 11 , wherein the first period is between about 5 seconds and about 30 seconds.

15. The method of claim 14 , wherein the ramp-down period, the second period, and the ramp-up period total about 5 seconds.

16. The method of claim 15 , wherein the second speed is about 80% of the first speed.

17. The method of claim 15 , wherein the second speed is about 85% of the first speed.

18. The method of claim 11 , wherein the ramp-down period, the second period, and the ramp-up period total between about 4 seconds and about 10 seconds.

19. The method of claim 11 , further comprising the step of setting the first and second speeds and the first and second periods by choosing one of a plurality of preset operating profiles and actuating a control circuit associated with the pump to operate the pump according to the chosen profile.

20. The method of claim 19 , wherein the plurality of preset operating profiles includes:
(i) a first preset operating profile in which the first period is about 10 seconds, the ramp-down period, the second period, and the ramp-up period total about 5 seconds, and the second speed is about 80% of the first speed,
(ii) a second preset operating profile in which the first period is about 10 seconds, the ramp-down period, the second period, and the ramp-up period total about 5 seconds, and the second speed is about 85% of the first speed, and
(iii) a third preset operating profile in which the first period is about 30 seconds, the ramp-down period, the second period, and the ramp-up period total about 5 seconds, and the second speed is about 85% of the first speed.

21. The method of claim 11 , wherein the first flow rate is no more than 3 liters per minute greater than the second flow rate.

22. The ventricular assist device of claim 1 , wherein the first and second speeds predetermined.

23. The method of claim 11 , wherein the first and second speeds are predetermined.

Assignees

• Heartware Inc

Inventors

• Voskoboynikov Neil
• Graham Joel

Classifications

• A61M1/1086 Primary

  Human Necessities · mapped topic

• G06F19/3406

  Physics · mapped topic

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M2205/3365

  Rotational speed · CPC title

• G16H40/63 Primary

  for local operation · CPC title