Colon-targeted active agent delivery carrier and uses thereof
US-2024390501-A1 · Nov 28, 2024 · US
US9433682B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9433682-B2 |
| Application number | US-201313775560-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 25, 2013 |
| Priority date | Feb 23, 2012 |
| Publication date | Sep 6, 2016 |
| Grant date | Sep 6, 2016 |
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Provided herein is a hydrogel composition comprising a graphene, a chitosan, and a polyethylene (glycol) diacrylate (PEGDA) (PCG hydrogel). In some embodiments, the hydrogel further comprises a N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided is a method for differentiating a mesenchymal stem cell comprising contacting the cell with the PCG hydrogel. Further provided herein is a method for delivering a pharmaceutical composition to a cell comprising administering to the cell a TPCG hydrogel and the pharmaceutical composition.
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The invention claimed is: 1. A hydrogel composition comprising: at least two acrylated chitosan-graphene monomers, where each chitosan-graphene monomer comprises: carboxylic acid functionalized graphene, where the chitosan component of the chitosan graphene-monomer is covalently bonded to the carboxylic acid functionalized graphene component of the chitosan-graphene monomer; and polyethylene (glycol) diacrylate (PEGDA), where the PEGDA covalently crosslinks the at least two ac…
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