Method for promoting synthesis of tissue collagen

Patent metadata

Field	Value
Publication number	US-9433605-B2
Application number	US-201313856566-A
Country	US
Kind code	B2
Filing date	Apr 4, 2013
Priority date	Mar 23, 2006
Publication date	Sep 6, 2016
Grant date	Sep 6, 2016

Abstract

An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.

First claim

The invention claimed is:

1. A method for promoting synthesis of tissue collagen in skin, which comprises orally administering to a human having skin wrinkles or sagging an effective amount of a composition comprising hydroxyproline or a salt thereof, wherein
said hydroxyproline or salt thereof being the only active ingredients in said composition,
said skin wrinkles or sagging are induced by aging, and
the tissue collagen synthesized improves said skin wrinkles or sagging.

2. The method according to claim 1 , wherein said composition comprises 0.5 to 70% by weight of hydroxyproline or a salt thereof as an active ingredient; and
a comestible carrier comprising at least one member selected from the group consisting of excipients, binders, disintegrating agents, lubricants, dispersants, suspending agents, emulsifiers, diluents, buffers, antioxidants and bacterial inhibitors, wherein
said oral preparation is in the form of a tablet, powder, granule, emulsion, syrup or capsule.

3. The method according to claim 1 , wherein said composition is a solid.

4. The method according to claim 1 , wherein 5 to 5,000 mg of said hydroxyproline or salt thereof is administered to said human per day.

5. The method according to claim 4 , wherein said hydroxyproline or salt thereof is administered to said human at 0.1 to 100 mg per kg body weight per day.

6. The method according to claim 5 , wherein 50 to 5,000 mg of said hydroxyproline or salt thereof is administered to said human per day.

7. The method according to claim 6 , wherein said hydroxyproline or salt thereof is administered to said human at 1 to 100 mg per kg body weight per day.

8. The method according to claim 7 , wherein 500 to 5,000 mg of said hydroxyproline or salt thereof is administered to said human per day.

9. The method according to claim 8 , wherein said hydroxyproline or salt thereof is administered to said human at 10 to 100 mg per kg body weight per day.

10. The method according to claim 1 , wherein said composition comprises said hydroxyproline salt, said salt being selected from the group consisting of hydrochloride, sulfate, nitrate, phosphate, acetate, maleate, fumarate, citrate, malate, lactate, α-ketoglutarate, gluconate, caprylate, sodium, potassium, magnesium, calcium, aluminum, zinc, ammonium, tetramethylammonium, morpholine, piperidine, glycine, phenylalanine, lysine, asparate and glutamate salts.

11. The method according to claim 1 , wherein said composition further comprises at least one member selected from the group consisting of sucrose, sorbitol, fructose, polyethylene glycol, propylene glycol, sesame oil, olive oil, soybean oil, p-hydroxybenzoate, strawberry flavor and peppermint.

12. The method according to claim 3 , wherein said composition further comprises at least one member selected from the group consisting of lactose, white sugar, glucose, sucrose, mannitol, sorbitol, potato starch, wheat starch, corn starch, calcium carbonate, calcium sulfate, sodium hydrogencarbonate, sodium chloride, licorice powder, gentian powder, agar, gelatin powder, crystalline cellulose, carmellose sodium, carmellose calcium, sodium alginate, magnesium stearate, talc, hydrogenated vegetable oil, macrogol, silicone oil, polyvinyl alcohol, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, fatty acid esters and glycerin.

Assignees

• Kyowa Hakko Bio Co Ltd

Inventors

• Kamiya Toshikazu
• Kamimura Ayako
• Kawada Yoko

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61P17/18

  Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00) · CPC title

• A23G3/36

  characterised by the composition {containing organic or inorganic compounds} · CPC title