Blood analysis apparatus

Patent metadata

Field	Value
Publication number	US-9429579-B2
Application number	US-31117507-A
Country	US
Kind code	B2
Filing date	Sep 20, 2007
Priority date	Sep 22, 2006
Publication date	Aug 30, 2016
Grant date	Aug 30, 2016

Abstract

The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13 . The blood analysis apparatus X is preferably configured to simultaneously carry out sample preparations for concentration measurement of the glucose and the glycohemoglobin by one sample preparation. The blood analysis apparatus X may be configured to perform dilution of a blood sample for measuring the glycohemoglobin and dilution of a blood sample for measuring the glucose using the same diluent.

First claim

What is claimed is:

1. A blood analysis apparatus comprising:
a sampling unit configured to sample a blood sample by obtaining a specimen from the blood sample;
a preparation unit configured to dilute and prepare the specimen to produce as a measurement sample a first measurement sample for measuring a ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen and a second measurement sample for measuring a concentration of glucose of the specimen;
a glycohemoglobin measuring unit configured to measure the ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen from the first measurement sample; and
a glucose measuring unit configured to measure the concentration of glucose of the specimen from the second measurement sample, wherein
the glucose measuring unit comprises an enzyme electrode for the measurement of the concentration of glucose,
the preparation unit comprises a dilution bath,
the blood analysis apparatus further comprises a sample injection valve for introducing the first measurement sample prepared in the dilution bath of the preparation unit to the glycohemoglobin measuring unit, a pipe for connecting the sample injection valve and the dilution bath, and a sample introducing pump for introducing the first measurement sample from the dilution bath to the sample injection valve,
the enzyme electrode is provided at the dilution bath, and
the dilution bath is connected to a drain system via an open/close valve that is provided at an upper part of the dilution bath, wherein the open/close valve, when in an opened state, causes excessively supplied cleaning fluid to be discarded to the drain system when the cleaning fluid is supplied to the dilution bath.

2. The blood analysis apparatus according to claim 1 , wherein the measurement sample is prepared by the preparation unit by diluting the specimen with a diluent.

3. The blood analysis apparatus according to claim 2 , wherein the diluent is also used as the cleaning fluid of a flow path through which the measurement sample moves.

4. The blood analysis apparatus according to claim 3 , wherein the diluent contains a supporting electrolyte.

5. The blood analysis apparatus according to claim 3 , wherein the diluent has a buffering ability.

6. The blood analysis apparatus according to claim 3 , wherein the diluent contains an antiseptic.

7. The blood analysis apparatus according to claim 6 , wherein the antiseptic is Na azide.

8. The blood analysis apparatus according to claim 3 , wherein the blood sample that the blood analysis apparatus is configured to analyze contains blood cells.

9. The blood analysis apparatus according to claim 8 , wherein the diluent contains a surface acting agent for hemolyzing the blood cells.

10. The blood analysis apparatus according to claim 8 , wherein the preparation unit includes a stirring unit configured to completely or almost completely hemolyze the blood cells when diluting the specimen.

11. The blood analysis apparatus according to claim 8 , wherein the preparation unit includes a stirring unit configured to stir the blood sample to make the blood cell concentration in the specimen uniform.

12. The blood analysis apparatus according to claim 1 , wherein the concentration of glucose is measured using an enzyme electrode method.

13. The blood analysis apparatus according to claim 1 , further comprising a temperature adjustment unit for simultaneously controlling temperatures of the enzyme electrode and the glycohemoglobin measuring unit.

14. The blood analysis apparatus according to claim 1 , wherein the glycohemoglobin measuring unit is configured to measure the ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen using a liquid chromatography method.

15. The blood analysis apparatus according to claim 14 , wherein the blood analysis apparatus is configured to simultaneously measure a hemoglobin concentration of the whole blood sample and correct the glucose whole blood measurement result to the plasma conversion value using the hemoglobin concentration.

16. The blood analysis apparatus according to claim 15 , wherein the hemoglobin concentration is obtained based on a chromatogram obtained in the measurement of the ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen.

17. The blood analysis apparatus according to claim 1 , wherein the blood analysis apparatus outputs a measurement result of the concentration of glucose and a measurement result of the ratio of glycohemoglobin are simultaneously for every patient.

18. The blood analysis apparatus according to claim 1 , wherein the blood analysis apparatus measures the concentration of glucose first, and then the blood analysis apparatus measures the ratio of a content of the glycohemoglobin to a content of hemoglobin in the specimen.

19. The blood analysis apparatus according to claim 18 , wherein the blood analysis apparatus makes a determination of whether to perform or cancel the measurement of the ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen based on a measurement result of the concentration of glucose.

20. The blood analysis apparatus according to claim 19 , wherein the blood analysis apparatus makes a determination on whether to perform or cancel the measurement of the ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen based on a disease type classification flowchart in a diagnosis of diabetes.

21. The blood analysis apparatus according to claim 20 , wherein the blood analysis apparatus makes a determination result of the disease classification of the diabetes is simultaneously output with the measurement result of the concentration of glucose and the measurement result of the ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen.

22. The blood analysis apparatus according to claim 1 , wherein
the preparation unit is configured to dilute and prepare the specimen to produce the measurement sample, the specimen being simultaneously diluted and prepared by the preparation unit for measuring a concentration of glucose of the specimen and for measuring a ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen by one sample preparation;
the glycohemoglobin measuring unit is configured to measure the ratio of glycohemoglobin of the specimen from a first portion of the measurement sample; and
the glucose measuring unit is configured to measure the concentration of glucose of the specimen from a second portion of the measurement sample.

23. The blood analysis apparatus according to claim 1 , wherein
the blood analysis apparatus is configured to use a whole blood sample for the blood sample, and
the blood analysis apparatus is configured to correct a glucose whole blood measurement result to a plasma conversion value using the ratio of a content of glycohemoglobin to a content of hemoglobin in the specimen.

24. The blood analysis apparatus according to claim 1 , wherein the dilution bath is further connected to the drain system via an open/close valve that is provided at a bottom part of the dilution bath.

Assignees

• Sugiyama Koji
• Kamata Tatsuo
• Takagi Takeshi
• Arkray Inc

Inventors

• Sugiyama Koji
• Kamata Tatsuo
• Takagi Takeshi

Classifications

• G01N2030/8822

  involving blood · CPC title

• G01N2800/042

  Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism · CPC title

• G01N33/723

  Glycosylated haemoglobin · CPC title

• G01N33/66 Primary

  involving blood sugars, e.g. galactose · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title