Method of treating Crohn's disease by administering an anti-IL-12 antibody

Patent metadata

Field	Value
Publication number	US-9428579-B2
Application number	US-201414512757-A
Country	US
Kind code	B2
Filing date	Oct 13, 2014
Priority date	Aug 7, 2000
Publication date	Aug 30, 2016
Grant date	Aug 30, 2016

Abstract

An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

First claim

What is claimed is:

1. A method for reducing symptoms of Crohn's disease in an animal, comprising administering a composition comprising an effective amount of an isolated anti-IL-12 antibody, wherein said antibody binds to a conformational epitope of IL-12 protein comprising residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of SEQ ID NO:9, to said animal.

2. The method according to claim 1 , wherein said effective amount is 0.001-50 mg/kilogram of said animal.

3. The method according to claim 1 , wherein said administering is by at least one mode selected from parenteral, subcutaneous, intramuscular, intravenous, intrarticular, intracapsular, intracartilaginous, intracavitary, intraosteal, intrapelvic, intraperitoneal, intraspinal, intrasynovial, buccal, sublingual, intranasal, and transdermal.

4. The method according to claim 1 , further comprising administering at least one composition comprising an effective amount of at least one compound or protein selected from the group consisting of a detectable label or reporter, a TNF antagonist, an antirheumatic, a muscle relaxant, a narcotic, a non-steroid anti-inflammatory drug (NSAID), an analgesic, an anesthetic, a sedative, a local anesthetic, a neuromuscular blocker, an antimicrobial, an antipsoriatic, a corticosteriod, an anabolic steroid, an immunization, an immunoglobulin, an immunosuppressive, a growth hormone, a hormone replacement drug, a radiopharmaceutical, a beta agonist, an inhaled steroid, an epinephrine or analog, a cytokine, and a cytokine antagonist.

5. A method for reducing symptoms of Crohn's disease in an animal, comprising administering a composition comprising an effective amount of an isolated anti-IL-12 antibody, wherein said antibody binds to a conformational epitope of IL-12 protein comprising residues 23, 40, 43, 45, 59, and 62 of the amino acid sequence of SEQ ID NO:9, to said animal.

6. The method according to claim 5 , wherein said effective amount is 0.001-50 mg/kilogram of said animal.

7. The method according to claim 5 , wherein said administering is by at least one mode selected from parenteral, subcutaneous, intramuscular, intravenous, intrarticular, intracapsular, intracartilaginous, intracavitary, intraosteal, intrapelvic, intraperitoneal, intraspinal, intrasynovial, buccal, sublingual, intranasal, and transdermal.

8. The method according to claim 5 , further comprising administering at least one composition comprising an effective amount of at least one compound or protein selected from the group consisting of a detectable label or reporter, a TNF antagonist, an antirheumatic, a muscle relaxant, a narcotic, a non-steroid anti-inflammatory drug (NSAID), an analgesic, an anesthetic, a sedative, a local anesthetic, a neuromuscular blocker, an antimicrobial, an antipsoriatic, a corticosteriod, an anabolic steroid, an immunization, an immunoglobulin, an immunosuppressive, a growth hormone, a hormone replacement drug, a radiopharmaceutical, a beta agonist, an inhaled steroid, an epinephrine or analog, a cytokine, and a cytokine antagonist.

Assignees

• Janssen Biotech Inc

Inventors

• Giles-Komar Jill
• Heavner George
• Knight David
• Luo Jinquan
• Peritt David
• Scallon Bernard
• Shealy David

Classifications

• A61P35/02

  specific for leukemia · CPC title

• A61P5/00

  Drugs for disorders of the endocrine system · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title