Method for reducing the occurrence of infection in young children

Patent metadata

Field	Value
Publication number	US-9427445-B2
Application number	US-201214127897-A
Country	US
Kind code	B2
Filing date	Jun 22, 2012
Priority date	Jun 22, 2011
Publication date	Aug 30, 2016
Grant date	Aug 30, 2016

Abstract

The invention pertains to the use of a composition in reducing the number of infections episodes and the occurrence of infections in young children, said composition comprising: (a) long chain polyunsaturated fatty acids, wherein the amount of arachidonic acid is less than 0.06 gram per 100 gram fatty acid; and comprising, per 100 g fatty acids: (i) 0.3-0.6 gram docosahexaenoic acid; (ii) 0.2-0.4 gram eicosapentaenoic acid; and (b) between 1.5 and 2.5 gram indigestible oligosaccharides per 100 kcal, comprising: (i) 1.4-2 gram short-chain galactooligosaccharides; and (ii) 0.1-0.5 gram long-chain fructopolysaccharides.

First claim

The invention claimed is:

1. A method for reducing occurrence of respiratory tract or intestinal infection in young children, reducing number of infectious episodes in respiratory tract or intestine in young children, and/or treatment of respiratory tract or intestinal infections in young children, the method comprising administering to young children suffering from respiratory tract infections a composition comprising:
(a) long chain polyunsaturated fatty acids (LC-PUFAs) with 20 and 22 carbon atoms, comprising less than 0.06 gram arachidonic acid (ARA) per 100 gram total fatty acid; and
(i) 0.3-0.6 gram docosahexaenoic acid (DHA, n-3) per 100 g total fatty acids; and
(ii) 0.2-0.4 gram eicosapentaenoic acid (EPA, n-3) per 100 g total fatty acids;
wherein the weight ratio of ARA:DHA is below 0.1 and the weight ratio of ARA:EPA is below 0.2;
and one of (b1) or (b2):

(b1) between 1.5 and 2.5 gram per 100 kcal indigestible oligosaccharides, comprising:
(i) 1.4-2 gram galactooligosaccharides with a degree of polymerization of 2-7; and
(ii) 0.1-0.5 gram fructopolysaccharides with a degree of polymerization of 2-150; or

(b2) a daily amount of between 4 and 8 gram indigestible oligosaccharides, comprising, per day:
(i) 3.7-6.4 gram galactooligosaccharides with a degree of polymerization of 2-7; and
(ii) 0.3-1.6 gram fructopolysaccharides with a degree of polymerization of 2-150.

2. The method according to claim 1 , wherein at least 80 wt % of the LC-PUFAs is provided by a combination of EPA and DHA.

3. The method according to claim 1 , wherein the composition comprising 0.01-0.2 gram docosapentaenoic acid (DPA, n-3) per 100 g total fatty acids.

4. The method according to claim 1 , wherein the composition comprising 0.25-0.35 g EPA and 0.35-0.55 g DHA per 100 g total fatty acids.

5. The method according to claim 1 , wherein at least 95 wt % of the indigestible oligosaccharides is provided by the galactooligosaccharides and fructopolysaccharides.

6. The method according to claim 1 , wherein the composition comprising 8-10 en % protein, 45-55 en % carbohydrates and 35-45 en % fat; and has a caloric value of 0.5-0.75 kcal per 100 ml.

7. The method according to claim 1 , wherein the composition has an omega-6 LC-PUFA:omega-3 LC-PUFA weight ratio other than ARA:DHA and ARA:EPA between 1:1 and 7:1.

8. The method according to claim 1 , wherein the composition has a weight ratio of DHA:EPA in a range of 1:1 to 2:1.

9. The method according to claim 1 , wherein the composition further comprises vitamin D.

10. The method according to claim 9 , wherein the composition comprises vitamin D in a daily dosage of 200-800 μg.

Assignees

• Sijben Johannes Wilhelmus Christina
• Alles Martine Sandra
• Nutricia Nv

Inventors

• Sijben Johannes Wilhelmus Christina
• Alles Martine Sandra

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• C12H1/22

  Ageing or ripening by storing, e.g. lagering of beer · CPC title

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title

• A23L33/22

  Comminuted fibrous parts of plants, e.g. bagasse or pulp · CPC title