Methods and compositions for modifying sensorial perception

Patent metadata

Field	Value
Publication number	US-9427415-B2
Application number	US-201514666394-A
Country	US
Kind code	B2
Filing date	Mar 24, 2015
Priority date	Apr 1, 2014
Publication date	Aug 30, 2016
Grant date	Aug 30, 2016

Abstract

Compounds and methods for modifying sensory perception associated with transient sensory receptors TRPA1, TRPV1, and TRPA1V1. A method for screening compounds for modulation of TRPA1, TRPV1, and/or TRPA1V1. Compositions comprising TRPA1V1 agonists or antagonists, for modifying sensory perception of the compositions.

First claim

What is claimed is:

1. A method of altering the sensory perception of burning, irritation, or pain from exposure to an oral care composition, the method comprising:
incorporating a compound that modulates TRPA1V1 activity into an oral care composition;
wherein the compound is trans,trans-2,4-undecadien-1-al;
wherein the compound is present in an amount effective to reduce the activation of TRPA1V1 relative to the activation of at least one of TRPA1 or TRPV1.

Assignees

• Procter & Gamble

Inventors

• Sreekrishna Koti Tatachar
• Lin Yakang

Classifications

• G01N2500/10

  involving cells · CPC title

• A61K31/11 Primary

  Aldehydes · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• G01N33/5041

  involving analysis of members of signalling pathways · CPC title

• G01N33/502

  for testing non-proliferative effects · CPC title