Accommodating intraocular composite lens and related methods

Patent metadata

Field	Value
Publication number	US-9427312-B2
Application number	US-201313896539-A
Country	US
Kind code	B2
Filing date	May 17, 2013
Priority date	May 25, 2012
Publication date	Aug 30, 2016
Grant date	Aug 30, 2016

Abstract

An implantable intraocular lens and methods of manufacturing them provide a target degree of optical accommodation. In various embodiments, the lens includes at least one internal optic, an outer shell for enclosing at least a portion of the internal optic, and a fluid at least partially filling the outer shell.

First claim

What is claimed is:

1. An implantable intraocular lens comprising:
an outer shell comprising at least a first external-access refill valve;
at least one internal fluid-filled lens including a portion integrated with at least a portion of the outer shell and comprising at least a second external-access refill valve distinct from the first external-access refill valve, the integrated portion of the intraocular lens being thicker and less flexible than, and accommodating differently from, unintegrated portions of the intraocular lens; and
a first fluid at least partially filling the outer shell,
wherein a refractive index of the first fluid, a degree of filling of the outer shell with the first fluid, a curvature of the outer shell, an axial position of the at least one internal fluid-filled lens, and a curvature of the at least one internal fluid-filled lens cooperate to define an accommodation and a refractive power of the intraocular lens.

2. The implantable intraocular lens of claim 1 , wherein the at least one internal fluid-filled lens is made of a curable material.

3. The implantable intraocular lens of claim 1 , wherein, the at least one internal fluid-filled lens is a diverging lens.

4. The implantable intraocular lens of claim 1 , wherein the at least one internal fluid-filled lens comprises a second shell at least partially filled with a second fluid, the first and second fluids exhibiting mutual repulsion therebetween.

5. The implantable intraocular lens of claim 4 , wherein the second external-access refill valve allows selective passage therethrough of the second fluid.

6. The implantable intraocular lens of claim 5 , wherein the first and second fluids have different refractive indices.

7. The implantable intraocular lens of claim 1 , wherein the at least first external-access refill valve allows selective passage therethrough of the first fluid.

8. The implantable intraocular lens of claim 1 , wherein a refractive index of the first fluid is different from that of an aqueous humor in an eye.

9. The implantable intraocular lens of claim 1 , wherein an outer surface of the outer shell comprises a feature creating a discontinuity thereon.

10. The implantable intraocular lens of claim 1 , wherein an outer surface of the outer shell comprises an adhesive.

11. The implantable intraocular lens of claim 1 , wherein an outer surface of the outer shell is modified with functional groups to prevent proliferation or migration of lens epithelial cells.

12. The implantable intraocular lens of claim 1 , wherein the first fluid is a pharmacological agent.

13. The implantable intraocular lens of claim 1 , wherein the at least one internal fluid-filled lens consists of two optics, the optics being integrated with opposed inner surfaces of the outer shell whereby a change in relative position between the optics alters the accommodation.

14. The implantable intraocular lens of claim 1 , wherein the outer shell is shaped to conform to a geometry of an eye.

15. The implantable intraocular lens of claim 1 , wherein at least one of the outer shell, the at least one internal fluid-filled lens, or the first fluid comprises at least one blue-light-absorbing chromophore.

16. The implantable intraocular lens of claim 1 , wherein the accommodation and refractive power of the intraocular lens is further defined by a degree of filling of the at least one internal fluid-filled lens.

17. The implantable intraocular lens of claim 1 , wherein the at least one internal fluid-filled lens is integrated with an anterior surface of the outer shell.

18. The implantable intraocular lens of claim 17 , further comprising a second internal fluid-filled lens including a second portion integrated with at least a portion of a posterior surface of the Outer shell and comprising at least a third external-access refill valve, the second integrated portion of the intraocular lens being thicker and less flexible than, and accommodating differently from, unintegrated portions of the intraocular lens.

Assignees

• Deboer Charles
• Tai Yu-Chong
• Humayun Mark S
• California Inst Of Techn
• Univ Southern California

Inventors

• Deboer Charles
• Tai Yu-Chong
• Humayun Mark S

Classifications

• A61F2/1624

  having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside · CPC title

• A61F2/1613 Primary

  having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus · CPC title

• A61F2/1648

  Multipart lenses · CPC title

• A61F2/1629

  for changing longitudinal position, i.e. along the visual axis when implanted · CPC title

• A61F2/1616 Primary

  Pseudo-accommodative, e.g. multifocal or enabling monovision · CPC title