Apparatus for oxygenation and perfusion of tissue for organ preservation

Patent metadata

Field	Value
Publication number	US-9426979-B2
Application number	US-201514796214-A
Country	US
Kind code	B2
Filing date	Jul 10, 2015
Priority date	Mar 15, 2011
Publication date	Aug 30, 2016
Grant date	Aug 30, 2016

Abstract

An apparatus according to an embodiment is configured to oxygenate and perfuse a bodily tissue for extracorporeal preservation of the bodily tissue. The apparatus includes a pneumatic system, a pumping chamber, and an organ chamber. The pneumatic system is configured for the controlled delivery of fluid to and from the pumping chamber based on a predetermined control scheme. The predetermined control scheme can be, for example, a time-based control scheme or a pressure-based control scheme. The pumping chamber is configured to diffuse a gas into a perfusate and to generate a pulse wave for moving the perfusate through a bodily tissue. The organ chamber is configured to receive the bodily tissue and the perfusate. The organ chamber is configured to substantially automatically purge excess fluid from the organ chamber to the pumping chamber. The pumping chamber is configured to substantially automatically purge excess fluid from the pumping chamber to an area external to the apparatus.

First claim

What is claimed is:

1. A connection system for connecting components of an organ transport system, the connection system comprising:
an organ transport container comprising a top portion and a bottom portion, the top and bottom portions configured to fit together to define an inner volume for containing an organ, the container further comprising a first mechanical connector and a first electrical connector;
a transporter comprising:
a transporter body sized and configured to receive the container;
a second mechanical connector and a second electrical connector;
a latch configured to secure the container in place within the transporter; and

an organ preservation apparatus sized and configured to fit within the organ transport container, the apparatus comprising:
a canister; and
a lid assembly comprising a third mechanical connector and a third electrical connector;

wherein when the transporter body is secured in the container by the latch, the transporter body and the container are configured to be oriented such that the first and second electrical and mechanical connectors are aligned; and
wherein the third mechanical connector of the lid assembly is configured to connect with a fourth mechanical connector located within the inner volume of the container, thereby aligning the third electrical connector of the lid assembly with a fourth electrical connector located within the inner volume of the container; and
wherein when the top portion and bottom portion of the container are fit together, the apparatus is secured in place, thereby securing the alignment of the connectors.

2. The connection system of claim 1 , wherein each connecting pair of mechanical connectors comprises a male connector and a female connector.

3. The connection system of claim 2 , wherein the first and third mechanical connectors comprise female connectors, and wherein the second and fourth mechanical connectors comprise male connectors.

4. The connection system of claim 1 , wherein the mechanical connectors comprise pneumatic passageways, and wherein the second mechanical connector is coupled to a fluid source.

5. The connection system of claim 4 , wherein when all of the mechanical connections are made, the fluid source is in fluid communication with the lid assembly.

6. The connection system of claim 5 , wherein the lid assembly further comprises a pumping chamber for pumping a fluid into a perfusate.

7. The connection system of claim 4 , wherein the fluid is oxygen.

8. The connection system of claim 4 , wherein each mechanical connector comprises a plurality of pneumatic passageways, at least one of the passageways comprising a fluid supply port and at least one of the passageways comprising a fluid vent port.

9. The connection system of claim 1 , wherein the transporter further comprises a power source.

10. The connection system of claim 1 , wherein the transporter further comprises a power source, and wherein when all electrical connections are made, the power source is in electrical communication with the lid assembly.

11. The connection system of claim 10 , wherein the power source powers a valve to switch between a fluid-delivery configuration and a fluid-venting configuration of the pneumatic passageways.

12. The connection system of claim 1 , wherein the latch secures the container in place when the container is inserted into the transporter.

13. The connection system of claim 1 , wherein the latch is configured to be manually released for removing the container.

Assignees

• Paragonix Tech Inc

Inventors

• Anderson Lisa M
• Judson Jared Alden

Classifications

• A01N1/143 Primary

  for organ perfusion · CPC title

• A01N1/0247 Primary

  Human Necessities · mapped topic