Dual responsive block copolymer compositions

Patent metadata

Field	Value
Publication number	US-9422387-B2
Application number	US-201313851186-A
Country	US
Kind code	B2
Filing date	Mar 27, 2013
Priority date	Mar 30, 2012
Publication date	Aug 23, 2016
Grant date	Aug 23, 2016

Abstract

A composition includes a responsive block copolymer, the responsive block copolymer including at least one block A that is a triggerable copolymer, the triggerable copolymer including at least one lower critical solution temperature monomer and at least one charged monomer, wherein the triggerable copolymer block A is a dual trigger block configured to trigger on temperature and ionic strength, and wherein the responsive block copolymer micellizes or gels at a temperature between 28° C. and 37° C. and a salt concentration of about 0.9 wt %.

First claim

What is claimed is:

1. A composition comprising a responsive block copolymer, the responsive block copolymer comprising at least one block A that is a triggerable copolymer and at least one block B that is a hydrophilic copolymer including a monomer selected from the group consisting of 2-hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxyethyl acrylate, and poly(ethylene glycol) methyl ether acrylate, the triggerable copolymer comprising at least one lower critical solution temperature monomer that is an oligoethylene oxide-based (meth)acrylate and at least one charged monomer, wherein the triggerable copolymer block A is a dual trigger block configured to trigger on temperature and ionic strength, and wherein the responsive block copolymer micellizes or gels at a temperature between 28 ° C. and 37 ° C. and a salt concentration of about 0.9 wt %.

2. The composition of claim 1 , wherein the responsive block copolymer is a diblock copolymer.

3. The composition of claim 1 , wherein the responsive block copolymer is a triblock copolymer.

4. The composition of claim 1 , wherein the responsive block copolymer is in the form A-B.

5. The composition of claim 1 , wherein the responsive block copolymer is in the form A-B-A.

6. The composition of claim 1 , wherein the responsive block copolymer is in the form B-A-B.

7. The composition of claim 1 , wherein the responsive block copolymer micellizes or gels at a temperature above 30 ° C. at approximately 0.9 wt % sodium chloride.

8. The composition of claim 1 , wherein the responsive block copolymer micellizes or gels at a temperature between 30 ° C. and 35 ° C. and at a salt concentration of about 0.9 wt %.

9. The composition of claim 1 , wherein the oligoethylene oxide-based (meth)acrylate is selected from di(ethylene glycol) methyl ether acrylate, di(ethylene glycol) ethyl ether acrylate, di(ethylene glycol) ethyl ether methacrylate, di(ethylene glycol) methyl ether methacrylate, tri(ethylene glycol) methyl ether acrylate, and tri(ethylene glycol) methyl ether methacrylate.

10. The composition of claim 1 , wherein the charged monomer is selected from acrylate, methacrylate, or acrylamide monomers with either cationic, zwitterionic, or anionic-functional groups.

11. A composition comprising a responsive block copolymer, the responsive block copolymer comprising a block A that is a triggerable copolymer and a block B that is a hydrophilic copolymer including a monomer selected from the group consisting of 2-hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxyethyl acrylate, and poly(ethylene glycol) methyl ether acrylate, the triggerable copolymer comprising at least one lower critical solution temperature monomer that is an oligoethylene oxide-based (meth)acrylate and at least one charged monomer, wherein the triggerable copolymer block A is a dual trigger block configured to trigger on temperature and ionic strength, and wherein the A block becomes insoluble at a temperature between 28 ° C. and 37 ° C. and a salt concentration of about 0.9 wt %.

12. The composition of claim 11 , wherein the responsive block copolymer further comprises a second triggerable block A.

13. The composition of claim 11 , wherein the responsive block copolymer is in the form A-B-A.

14. The composition of claim 11 , wherein the responsive block copolymer micellizes or gels at a temperature between 30 ° C. and 35 ° C. and at a salt concentration of about 0.9 wt %.

15. The composition of claim 11 , wherein the responsive block copolymer becomes insoluble at a temperature above 30 ° C. at approximately 0.9 wt % sodium chloride.

16. A composition comprising a responsive triblock copolymer, the responsive triblock copolymer comprising:
two blocks A that are each a triggerable copolymer, each triggerable copolymer comprising at least one lower critical solution temperature monomer and at least one charged monomer, wherein each triggerable copolymer block A is a dual trigger block configured to trigger on temperature and ionic strength; and
a hydrophilic copolymer block B including a monomer selected from the group consisting of 2-hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxyethyl acrylate, and poly(ethylene glycol) methyl ether acrylate, wherein the responsive block copolymer is in the form A-B-A, and wherein the responsive block copolymer gels at a temperature between 30 ° C. and 37 ° C. at approximately 0.9 wt % sodium chloride.

17. The composition of claim 16 , wherein the responsive block copolymer gels at a temperature between 30 ° C. and 35 ° C. and at a salt concentration of about 0.9 wt %.

Assignees

• Kimberly Clark Co

Inventors

• Bunyard William Clayton
• Long Timothy E
• Smith Adam E
• Cheng Shijing
• Hemp Sean T

Classifications

• C08F299/00 Primary

  Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers · CPC title

• C08F293/005 Primary

  using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent · CPC title

• C08F2438/03

  Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX] · CPC title

• C08G81/02

  at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds · CPC title

• C08L53/00

  Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers · CPC title