Epoxyeicosatrienoic acid analogs and methods of making and using the same
US-9127027-B2 · Sep 8, 2015 · US
Epoxyeicosatrienoic acid analogs and methods of making and using the same
US9422318B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9422318-B2 |
| Application number | US-201514813615-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 30, 2015 |
| Priority date | Apr 6, 2011 |
| Publication date | Aug 23, 2016 |
| Grant date | Aug 23, 2016 |
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Abstract
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Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
First claim
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What is claimed is: 1. A compound selected from the group consisting of 2. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier. 3. A method of reducing hypertension in a subject, comprising administering to a subject a therapeutically effective amount of a compound according to claim 1 , wherein hypertension in said subject is reduced. 4. A method of reducing nephrotoxicity in a subject, comprising administering to a subject a therapeutically effective amount of a compound according to claim 1 , wherein nephrotoxicity in said subject is reduced. 5. The method of claim 4 , wherein the nephrotoxicity is drug-induced. 6. The method of claim 4 , wherein the nephrotoxicity is cisplatin-induced. 7. A method of reducing cisplatin nephrotoxicity in a subject, comprising administering to a subject a therapeutically effective amount of a compound according to claim 1 , wherein cisplatin nephrotoxicity in said subject is reduced.
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Antihypertensives · CPC title
of the kidneys · CPC title
of an unsaturated carbon skeleton · CPC title
Five-membered rings · CPC title
- C07F9/40Primary
Esters thereof · CPC title
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- What does patent US9422318B2 cover?
- Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
- Who is the assignee on this patent?
- Medical College Wisconsin Inc, Univ Texas
- What technology area does this patent fall under?
- Primary CPC classification C07F9/40. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 23 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).