Compounds and methods for treating diseases mediated by protease activated receptors

Patent metadata

Field	Value
Publication number	US-9422262-B2
Application number	US-201113825574-A
Country	US
Kind code	B2
Filing date	Sep 23, 2011
Priority date	Sep 24, 2010
Publication date	Aug 23, 2016
Grant date	Aug 23, 2016

Abstract

The invention relates to the use of a compound of Formula I for the treatment of protease-activated receptor mediated diseases by the administration of a compound of Formula I or a prodrug or metabolite thereof.

First claim

What is claimed:

1. A method of treating a protease-activated receptor (PAR) mediated disease in a patient by administrating a therapeutically effective dose of compound selected from:

TABLE A

 1

 2

 3

 4

 5

 6

 7

 8

 9

10

11

12

13

14

23

24

25

26

wherein the PAR mediated disease is selected from acute Myocardial Infarction, acute occlusion following coronary angioplasty or stent placement thrombosis subsequent to or associated with a surgical procedure, and thrombosis associated with atrial fibrillation.

2. The method of claim 1 , wherein the patient is in need of inhibition of platelet activation.

3. The method of claim 1 , wherein the patient is in need of inhibition of thrombus formation.

4. The method of claim 1 , wherein said PAR mediated disease is acute Myocardial Infarction.

5. The method of claim 1 , wherein said PAR mediated disease is acute occlusion following coronary angioplasty or stent placement.

6. The method of claim 1 , wherein said PAR mediated disease is thrombosis subsequent to or associated with a surgical procedure.

7. The method of claim 1 , wherein said PAR mediated disease is thrombosis associated with atrial fibrillation.

Assignees

• Dockendorff Chris
• Flaumenhaft Robert
• Broad Inst Inc
• Beth Israel Deaconess Medical Ct Inc

Inventors

• Dockendorff Chris
• Flaumenhaft Robert
• Macpherson Lawrence

Classifications

• C07C233/88

  having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced · CPC title

• C07D207/34

  with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms · CPC title

• C07D333/38 Primary

  Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title

• A61K31/381

  having five-membered rings · CPC title

• C07D213/72

  Nitrogen atoms (nitro radicals C07D213/61) · CPC title