Microfluidic device with auxiliary and bypass channels

Patent metadata

Field	Value
Publication number	US-9421540-B2
Application number	US-201113881975-A
Country	US
Kind code	B2
Filing date	Aug 3, 2011
Priority date	Oct 28, 2010
Publication date	Aug 23, 2016
Grant date	Aug 23, 2016

Abstract

A microfluidic device is provided. The microfluidic device has: a flow inlet and a flow outlet; a bypass channel defining a first flow path away from the flow inlet and toward the flow outlet; and an auxiliary channel defining a second flow path away from the flow inlet and toward the flow outlet, wherein the auxiliary channel defines a reagent area adapted to receive a reagent, and wherein the auxiliary channel joins the bypass channel at a primary junction downstream from the reagent area and upstream from the flow outlet.

First claim

The invention claimed is:

1. A microfluidic device comprising:
a flow inlet and a flow outlet;
a bypass channel defining a first flow path away from the flow inlet and toward the flow outlet; and
an auxiliary channel defining a second flow path away from the flow inlet and toward the flow outlet,
wherein the auxiliary channel defines a reagent area adapted to receive a reagent,
wherein the auxiliary channel joins the bypass channel at a primary junction downstream from the reagent area and upstream from the flow outlet,
wherein a quarter-circle portion of the auxiliary channel joins a quarter-circle portion of the bypass channel at the primary junction to form a delay valve,
wherein the quarter-circle portion of the auxiliary channel and the quarter-circle portion of the bypass channel merge with an exit path having a greater width than a width of the quarter-circle portion of the auxiliary channel and a width of the quarter-circle portion of the bypass channel, and
wherein the auxiliary channel is adapted such that a flow rate of the auxiliary channel at the primary junction is smaller than a flow rate of the bypass channel at the primary junction.

2. The microfluidic device of claim 1 ,
wherein a portion of the auxiliary channel upstream from the reagent area defines a flow constriction area that constricts a flow of the second flow path relative to other areas in the portion of the auxiliary channel upstream from the reagent area.

3. The microfluidic device of claim 2 ,
wherein the auxiliary channel splits from the bypass channel at a split upstream from the reagent area, and
wherein the flow constriction area is arranged at or downstream from the split.

4. The microfluidic device of claim 1 , wherein the bypass channel, the auxiliary channel and the reagent area have a same depth.

5. The microfluidic device of claim 1 , wherein a width of each of the bypass channel and the auxiliary channel is between 10 and 100 micrometers.

6. The microfluidic device of claim 1 ,
further comprising a plurality of the bypass channel,
wherein the auxiliary channel joins at least one of the bypass channels at the primary junction, wherein the primary junction is located downstream from the reagent area, and
wherein the auxiliary channel joins at least one of the bypass channels at a secondary junction, wherein the secondary junction is located downstream from the primary junction.

7. The microfluidic device of claim 1 ,
further comprising a plurality of the bypass channel,
wherein at least a subset of the bypass channels have similar transverse sections.

8. The microfluidic device of claim 7 ,
wherein the auxiliary channel and the at least a subset of the bypass channels have similar transverse sections.

9. The microfluidic device of claim 1 ,
wherein the auxiliary channel is adapted to have a straight section, and
wherein the reagent area is defined in the straight section of the auxiliary channel.

10. A method comprising the steps of:
providing the microfluidic device according to claim 1 ;
depositing the reagent in the reagent area of the microfluidic device; and
letting a fluid flow from the flow inlet to the flow outlet to thereby carry the reagent downstream from the reagent area.

11. The method of claim 10 ,
further comprising a step of monitoring a chemical reaction downstream from the primary junction,
wherein the chemical reaction occurs due to the reagent carried by the fluid.

Assignees

• Delamarche Emmanuel
• Gervais Luc
• Hitzbleck Martina
• IBM

Inventors

• Delamarche Emmanuel
• Gervais Luc
• Hitzbleck Martina

Classifications

• Y10T436/2575

  Volumetric liquid transfer · CPC title

• B01L3/502746

  characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves · CPC title

• B01F13/0059

  Operations & Transport · mapped topic

• B01L2300/0864

  comprising only one inlet and multiple receiving wells, e.g. for separation, splitting · CPC title

• B01L2400/086

  using baffles or other fixed flow obstructions · CPC title