Reinforced biologic material

Patent metadata

Field	Value
Publication number	US-9421306-B2
Application number	US-201213616556-A
Country	US
Kind code	B2
Filing date	Sep 14, 2012
Priority date	Nov 21, 2008
Publication date	Aug 23, 2016
Grant date	Aug 23, 2016

Abstract

The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component.

First claim

What is claimed is:

1. An implantable medical device, comprising:
a plurality of first elongate non-biologic elements, at least a portion of which are under a tensile or compressive stress prior to implantation;
at least one biologic component comprising a biomatrix surrounding at least a portion of the plurality of first elongate non-biologic elements; and
at least one second elongate non-biologic element, wherein the at least one second element secures at least one end portion of the plurality of first elongate non-biologic elements;
wherein the plurality of first elongate non-biologic elements have a higher load capacity than the at least one biologic component at the time of implantation; and
wherein the at least one biologic component has a higher load capacity than the plurality of first elongate non-biologic elements after implantation and following growth of native cells within the biomatrix.

2. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprises at least one material chosen from bioabsorbable polymer, bioabsorbable metal, or a combination of bioabsorbable polymer and bioabsorbable metal.

3. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprise at least one material chosen from polyhydroxyalkanoate, poly-hydroxybutyrate, polylactic acid (PLA), polyglycolic acid (PGA), polylactideglycolide acid (PLGA), polydioxanone (PDO), polycaprolactone (PCL), a polyanhydride, a polyorthoester, a poly(amino acid), a polypeptide, a polydepsipeptide, a nylon-2/nylon-6 copolyamide, a poly(alkylene succinate), poly(hydroxyl butyrate) (PHB), poly(butylene diglocolate), poly(.epsilon.-caprolactone), a polydihydropyran, a polyphosphazene, a poly(cyano acrylates), modified polysaccharides, cellulose, starch, chitin, modified proteins, collagen, fibrin, and combinations and copolymers thereof.

4. The implantable medical device of claim 1 , wherein the biomatrix comprises an acellular tissue matrix or a particulate acellular tissue matrix.

5. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprises a bioabsorbable polymer, a bioabsorbable metal or a combination of a bioabsorbable polymer and bioabsorbable metal.

6. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements are under a tensile stress ranging from greater than 0 N to about 1800 N.

7. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprises a plurality of threads, cords, cables, ribbons, or braids.

8. The implantable medical device of claim 1 , wherein the at least one biologic component at least partially separates the elongate first elements comprised within the plurality of elongate first non-biologic elements.

9. The implantable medical device of claim 1 , wherein the at least one biologic component at least partially coats each element comprised within the plurality of first elongate non-biologic elements.

10. The implantable medical device of claim 1 , wherein the at least one biologic component is in the form of a coating, a paste, a powder, or a liquid.

11. The implantable medical device of claim 1 , wherein the at least one second elongate non-biologic element secures at least one end of the plurality of first elongate non-biologic elements by at least one of whipping, wrapping, and winding.

12. The implantable medical device of claim 1 , wherein the at least one second elongate non-biologic element comprises the same material as the plurality of first elongate non-biologic elements.

13. The implantable medical device of claim 1 , wherein at least a portion of the plurality of first elongate non-biologic elements are under a longitudinal tensile or compressive stress prior to implantation.

14. The implantable medical device of claim 1 , wherein at least a portion of the plurality of first elongate non-biologic elements are under a tensile or compressive stress of at least about 0.1 N prior to implantation.

15. The implantable medical device of claim 1 , wherein at least a portion of the plurality of first elongate non-biologic elements are under a tensile or compressive stress ranging from about 0.1 N to about 1800 N prior to implantation.

16. An implantable medical device, comprising:
a plurality of first elongate non-biologic elements, at least a portion of which are under a tensile or compressive stress prior to implantation;
at least one biologic component comprising a biomatrix surrounding at least a portion of the plurality of first elongate non-biologic elements; and
at least one second elongate non-biologic element, wherein the at least one second element secures at least one end portion of the plurality of first elongate non-biologic elements;
wherein the plurality of first elongate non-biologic elements have a higher load capacity than the at least one biologic component at the time of implantation;
wherein the at least one biologic component has a higher load capacity than the plurality of first elongate non-biologic elements after implantation and following growth of native cells within the biomatrix; and
wherein the at least one second elongate non-biologic element forms a screw-thread pattern compatible with threads of an anchoring screw.

Assignees

• Park Jason
• Barere Aaron
• Wagner Christopher T
• Kiefer Robert
• Greenhalgh E Skott
• Lifecell Corp

Inventors

• Park Jason
• Barere Aaron
• Wagner Christopher T
• Kiefer Robert
• Greenhalgh E Skott

Classifications

• A61L27/48 Primary

  with macromolecular fillers · CPC title

• B29L2031/7532

  Artificial members, protheses · CPC title

• A61L2430/10

  for reconstruction of tendons or ligaments · CPC title

• A61L27/44 Primary

  having a macromolecular matrix · CPC title

• B29C63/06

  around tubular articles · CPC title