Method of preparing iodine seed for treating eye disease or cancer, and iodine seed prepared thereby

Patent metadata

Field	Value
Publication number	US-9421282-B2
Application number	US-201313765072-A
Country	US
Kind code	B2
Filing date	Feb 12, 2013
Priority date	May 10, 2012
Publication date	Aug 23, 2016
Grant date	Aug 23, 2016

Abstract

The present invention provides a technique for adsorbing I-125 on a support for treating cancer and a method of preparing an I-125 seed using the same. Since a method of preparing iodine according to the present invention uses an intermediate having phosphate-based, oxalate-based, or arsenate-based anions introduced thereinto, the intermediate has a substitution effect of iodine 3 to 5 times higher than that of a typically used intermediate having chlorine anions introduced thereinto. According to the substitution effect, control of a radiation dose may be possible during the manufacturing of an iodine seed and an iodine seed may be prepared within a shorter period of time. Also, since an amount of residual radioactive iodine may be decreased as a result of a large amount of adsorption, an amount of radioactive iodine (I-125) waste may be decreased, and the effect thereof may be also high environmentally.

First claim

What is claimed is:

1. A method of preparing an iodine seed for treating eye disease or cancer, the method comprising:
introducing an anion selected from the group consisting of phosphates, oxalates, and arsenates into a surface of a support (step 1) to form an intermediate; and
substituting the anion of the intermediate obtained from step 1 with I-125 (step 2) to form an iodine seed,
wherein
the support is made of one selected from the group consisting of silver (Ag), ceramic containing silver, and heavy metal surface treated with silver, and
step 1 is performed by introducing a support into a solution, in which the anion selected from the group consisting of phosphates, oxalates, and arsenates is dissolved, and stirring to form the intermediate.

2. The method as set forth in claim 1 , wherein the forming of the intermediate in step 1 is performed after cleaning the support with distilled water or nitric acid.

3. The method as set forth in claim 1 , wherein the phosphate-based anions of step 1 are formed of one selected from the group consisting of phosphoric acid (H 3 PO 4 ), lithium phosphate (Li 3 PO 4 ), lithium dihydrogen phosphate (LiH 2 PO 4 ), dilithium hydrogen phosphate (Li 2 HPO 4 ), sodium phosphate (Na 3 PO 4 ), sodium dihydrogen phosphate (NaH 2 PO 4 ), disodium hydrogen phosphate (Na 2 HPO 4 ), potassium phosphate (K 3 PO 4 ), potassium dihydrogen phosphate (KH 2 PO 4 ), dipotassium hydrogen phosphate (K 2 HPO 4 ), ammonium dihydrogen phosphate ((NH 4 )H 2 PO 4 ), and diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ).

4. The method as set forth in claim 1 , wherein the oxalate-based anions of step 1 are formed of one selected from the group consisting of lithium oxalate (Li 2 C 2 O 4 ), sodium oxalate (Na 2 C 2 O 4 ), potassium oxalate (K 2 C 2 O 4 ), ammonium oxalate ((NH 4 ) 2 C 2 O 4 ), ferrous oxalate (FeC 2 O 4 ), strontium oxalate (SrC 2 O 4 ), tin oxalate (SnC 2 O 4 ), and barium oxalate (BaC 2 O 4 ).

5. The method as set forth in claim 1 , wherein the arsenate-based anions of step 1 are formed of one selected from the group consisting of potassium dihydrogen arsenate (KH 2 AsO 4 ), dipotassium hydrogen arsenate (K 2 HAsO 4 ), sodium dihydrogen arsenate (NaH 2 AsO 4 ), and disodium hydrogen arsenate (Na 2 HAsO 4 ).

6. The method as set forth in claim 1 , further comprising treating the surface of the support with an oxidant before introducing the anions into the surface of the support in step 1.

7. The method as set forth in claim 6 , wherein the oxidant is one or more selected from the group consisting of hydrogen peroxide, manganese peroxide, sodium chromate, and sodium bichromate.

8. The method as set forth in claim 1 , wherein the substituting of the anions of the intermediate with I-125 in step 2 is performed by introducing the intermediate in an I-125 solution and stirring.

9. The method as set forth in claim 1 , further comprising sealing the prepared iodine seed with titanium (Ti).

Assignees

• Choi Kang Hyuk
• Son Kwang Jae
• Lee Jin-Hee
• Nam Sung-Soo
• Choi Sun Ju
• Korea Atomic Energy Res

Inventors

• Choi Kang Hyuk
• Son Kwang Jae
• Lee Jin-Hee
• Nam Sung-Soo
• Choi Sun Ju

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• A61P27/02

  Ophthalmic agents · CPC title

• A61P13/08

  of the prostate · CPC title

• A61K51/02 Primary

  characterised by the carrier {, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus} · CPC title

• A61K51/1282

  Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents · CPC title