Zwitterionic polymers with therapeutic moieties

Patent metadata

Field	Value
Publication number	US-9416210-B2
Application number	US-200913131665-A
Country	US
Kind code	B2
Filing date	Dec 11, 2009
Priority date	Dec 12, 2008
Publication date	Aug 16, 2016
Grant date	Aug 16, 2016

Abstract

The invention generally relates to zwitterionic polymers (including zwitterionic copolymers), such as polymethacrylic structures, with pendent functional moieties, such as therapeutic or biologic moieties. More particularly, the invention relates to phosphorylcholine-substituted methacrylic polymers prepared by free radical polymerization and click chemistry, for example, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as biological or therapeutic agents and in drug delivery thereof.

First claim

What is claimed is:

1. A co-polymer comprising the structure of:

wherein
each of R 1 and R 3 is independently a hydrogen, alkyl, or halogen;
each of R 2 and R 4 is independently a hydrogen, (C 1 -C 15 ) alkyl, (C 1 -C 15 ) alkyloxy, or halogen;
R Z is a group comprising a zwitterionic moiety;
m is an integer from 1 to about 500;
n is an integer from 1 to about 100;
L q is a linking group;
R X is a group comprising an azide or a carbon-carbon triple bond;
L T is a linking group;
T is a targeting moiety towards a biological target; and
wherein T is selected from the group consisting of an antibody, protein, aptamer, or a small molecule comprising a folate moiety.

2. The co-polymer of claim 1 , wherein, L T comprises an amide moiety.

3. The co-polymer of claim 1 , wherein the co-polymer has a M n from about 5 kDa to about 100 kDa.

4. The polymer of claim 1 , wherein the polymer is crosslinked.

5. The polymer of claim 1 , wherein the polymer is a block-copolymer.

Assignees

• Emrick Todd
• Chen Xiangji
• Mcrae Samantha
• Univ Massachusetts

Inventors

• Emrick Todd
• Chen Xiangji
• Mcrae Samantha

Classifications

• A61K31/4745

  condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48) · CPC title

• C08F238/00

  Copolymers of compounds having one or more carbon-to-carbon triple bonds · CPC title

• A61K31/704

  attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} · CPC title

• C08F8/30

  Introducing nitrogen atoms or nitrogen-containing groups · CPC title

• C08F293/005

  using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent · CPC title