Antibody and antigen binding fragments thereof
US-2024385186-A1 · Nov 21, 2024 · US
Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
US9416195B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9416195-B2 |
| Application number | US-201313872265-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 29, 2013 |
| Priority date | Feb 23, 2007 |
| Publication date | Aug 16, 2016 |
| Grant date | Aug 16, 2016 |
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Abstract
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An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.
First claim
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What is claimed is: 1. A method of treating a disease associated with increased activity of matrix metalloproteinase-9 (MMP-9) or matrix metalloproteinase-2(MMP-2) in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an antibody comprising an antigen recognition region capable of specifically binding the compound having the Formula: wherein R is O—CH 2 —CH 2 —CONH—CH 2 —CH 2 —NH 2 , wherein the antibody is capable of inhibiting the activity of MMP-9 and MMP-2 with a IC50 of less than 5 μM, thereby treating a disease associated with increased activity of MMP-9 or MMP-2 in the subject. 2. The method of claim 1 , wherein the disease is an inflammatory bowel disease. 3. The method of claim 1 , wherein the disease is cancer that is associated with increased activity of MMP-9 and or MMP-2. 4. The method of claim 1 , wherein the disease is multiple sclerosis. 5. The method of claim 3 , wherein said cancer is a metastatic cancer that is associated with increased activity of MMP-9 and or MMP-2.
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Classifications
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specific for metastasis · CPC title
Antineoplastic agents · CPC title
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
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Frequently asked questions
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- What does patent US9416195B2 cover?
- An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.
- Who is the assignee on this patent?
- Yeda Res & Dev, Yeda Res & Dev
- What technology area does this patent fall under?
- Primary CPC classification C07K16/44. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 16 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).