Pharmaceutical composition for treatment and/or prevention of liver cancer
US-2015218285-A1 · Aug 6, 2015 · US
Pharmaceutical composition for treatment and prevention of cancers
US9416192B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9416192-B2 |
| Application number | US-200913057709-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 5, 2009 |
| Priority date | Aug 5, 2008 |
| Publication date | Aug 16, 2016 |
| Grant date | Aug 16, 2016 |
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- Title
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Abstract
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The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for treatment of a CAPRIN-1 expressing cancer in a subject, comprising administering to the subject an antibody or antigen-binding fragment thereof having an immunological reactivity with a CAPRIN-1 protein which has the amino acid sequence shown in any one of the even numbered SEQ ID NOS: 2 to 30, wherein the antibody or fragment specifically binds the CAPRIN-1 protein expressed on the cell surface of the cancer. 2. A method for treatment of a CAPRIN-1 expressing cancer in a subject, comprising administering to the subject a pharmaceutical composition comprising an antibody or antigen-binding fragment thereof having an immunological reactivity with a CAPRIN-1 protein which has the amino acid sequence shown in any one of the even numbered SEQ ID NOS: 2 to 30, wherein the antibody or fragment thereof specifically binds the CAPRIN-1 protein expressed on the cell surface of the cancer. 3. The method according to claim 1 , wherein the cancer is damaged by an antibody-dependent cell-mediated cytotoxicity (ADCC) activity of the antibody. 4. The method according to claim 1 , wherein the antibody is a monoclonal antibody or polyclonal antibody. 5. The method according to claim 1 , wherein the antibody is a human antibody, a humanized antibody, a chimeric antibody, a single-chain antibody, or a bispecific antibody. 6. The method according to claim 2 , wherein the cancer is damaged by an antibody-dependent cell-mediated cytotoxicity (ADCC) activity of the antibody. 7. The method according to claim 2 , wherein the antibody is a monoclonal antibody or polyclonal antibody. 8. The method according to claim 2 , wherein the antibody is a human antibody, a humanized antibody, a chimeric antibody, a single-chain antibody, or a bispecific antibody.
Assignees
Inventors
Classifications
Antineoplastic agents · CPC title
specific for leukemia · CPC title
Drugs for disorders of the nervous system · CPC title
Drugs for disorders of the respiratory system · CPC title
Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives · CPC title
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Frequently asked questions
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- What does patent US9416192B2 cover?
- The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
- Who is the assignee on this patent?
- Okano Fumiyoshi, Ido Takayoshi, Saito Takanori, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/30. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 16 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).