Macrocycles as factor xia inhibitors
US-2016362414-A1 · Dec 15, 2016 · US
Compositions and methods for inhibiting activity of hypoxia-inducible transcription factor complex and its use for treatment of tumors
US9416145B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9416145-B2 |
| Application number | US-201314424996-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 15, 2013 |
| Priority date | Aug 29, 2012 |
| Publication date | Aug 16, 2016 |
| Grant date | Aug 16, 2016 |
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- Title
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- Abstract
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Abstract
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Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound having the structure: 2. The compound of claim 1 having the structure: 3. The compound of claim 1 having the structure: 4. The compound of claim 1 having the structure: 5. The compound of claim 1 having the structure: 6. The compound of claim 1 having the structure: 7. The compound of claim 1 having the structure: 8. The compound of claim 1 having the structure: 9. A pharmaceutical composition comprising a compound of claim 1 dissolved or dispersed in a carrier. 10. The pharmaceutical composition of claim 9 , wherein the compound has the structure: 11. A method for treating breast cancer in a subject, comprising administering a therapeutically effective amount of a compound of claim 1 to the subject in need thereof. 12. The method of claim 11 , wherein the compound has the structure:
Assignees
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Classifications
Antineoplastic agents · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives · CPC title
- C07D513/08Primary
Bridged systems · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9416145B2 cover?
- Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes.
- Who is the assignee on this patent?
- Univ Southern California
- What technology area does this patent fall under?
- Primary CPC classification C07D513/08. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 16 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).