Drug-eluting stents for adenosine receptor modulation

Patent metadata

Field	Value
Publication number	US-9414901-B2
Application number	US-89650110-A
Country	US
Kind code	B2
Filing date	Oct 1, 2010
Priority date	Oct 1, 2009
Publication date	Aug 16, 2016
Grant date	Aug 16, 2016

Abstract

Drug eluting stents (DES) useful for the treatment of restenosis are described. The stents comprise biocompatible polymers and adenosine receptor modulators.

First claim

What is claimed is:

1. A device for implantation into a blood vessel, the device comprising a stent having a coating, where the coating consists of a biocompatible polymer that is poly(lactic-co-glycolic acid)-b-poly(L-lysinse) or polyurethane; 1,3-dipropyl-8-cyclopentyl xanthine (DPCPX); and optionally an adenosine A 2B receptor agonist or an adenosine A 2A receptor agonist,
wherein the DPCPX is released from the stent over a period of from about 7 days to about 100 days and the DPCPX has a surface density in the coating from 0.5 μg/mm 2 to 1 μg/mm 2 .

2. The device of claim 1 wherein the coating consists of poly(lactic-co-glycolic acid)-b-poly(L-lysine) or polyurethane; DPCPX; and an adenosine A 2B receptor agonist.

3. The device of claim 1 wherein the coating consists of poly(lactic-co-glycolic acid)-b-poly(L-lysine) or polyurethane; DPCPX; and an adenosine A 2A receptor agonist.

4. A device for implantation into a blood vessel, the device consisting of a stent coated with a coating consisting of a biocompatible polymer and DPCPX,
wherein the DPCPX is released from the stent over a period of from about 7 days to about 100 days and the biocompatible polymer is selected from the group consisting of poly(lactic-co-glycolic acid)-b-poly(L-lysine), polyurethane, poly(styrene-b-isobutylene-b-styrene), or a combination thereof.

5. A method of treating restenosis in a patient, the method comprising the step of implanting the device of claim 1 into a blood vessel of the patient.

6. The device of claim 1 wherein the DPCPX is present at a ratio of 10 wt % (DPCPX:polymer).

7. The device of claim 1 wherein the DPCPX is present at a ratio of 20 wt % (DPCPX:polymer).

8. The device of claim 1 wherein the DPCPX is present at a ratio of 30 wt % (DPCPX:polymer).

9. The device of claim 1 wherein the surface density is 0.5 μg/mm 2 or 1 μg/mm 2 .

10. The device of claim 1 wherein the surface density is 0.5 μg/mm 2 .

11. The device of claim 1 wherein the coating has a thickness from about 5 μm to about 50 μm.

12. The device of claim 1 wherein the biocompatible polymer is poly(lactic-co-glycolic acid)-b-poly(L-lysine).

13. The device of claim 4 wherein the biocompatible polymer is polyurethane.

14. The device of claim 4 wherein the biocompatible polymer is poly(lactic-co-glycolic acid)-b-poly(L-lysine).

15. The device of claim 4 wherein the DPCPX has a surface density in the coating from 0.5 μg/mm 2 to 1 μg/mm 2 .

16. The device of claim 4 wherein the DPCPX is present at a ratio of 10 wt % (DPCPX:polymer).

17. A device for implantation into a blood vessel, the device consisting of a stent coated with a coating consisting of a biocompatible polymer and DPCPX,
wherein the DPCPX is released from the stent over a period of from about 7 days to about 100 days, the biocompatible polymer is poly(lactic-co-glycolic acid)-b-poly(L-lysine), and the DPCPX has a surface density in the coating from 0.5 μg/mm 2 to 1 μg/mm 2 .

18. The device of claim 17 , wherein the surface density is 0.5 μg/mm 2 or 1 μg/mm 2 , the coating has a thickness from about 5 μm to about 50 μm, the biocompatible polymer is poly(lactic-co-glycolic acid)-b-poly(L-lysine), and the DPCPX is present at a ratio of 10 wt % (DPCPX:polymer).

Assignees

• Sturek Michael
• Park Kinam
• Univ Indiana Res & Tech Corp

Inventors

• Sturek Michael
• Park Kinam

Classifications

• A61K31/519

  ortho- or peri-condensed with heterocyclic rings · CPC title

• A61K31/44

  Non condensed pyridines; Hydrogenated derivatives thereof · CPC title

• A61F2/00 Primary

  Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (dental prostheses A61C13/00; artificial kidneys A61M1/14; artificial hearts A61M60/00) · CPC title

• A61K31/52

  Purines, e.g. adenine · CPC title

• A61K31/4545

  containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine · CPC title