Biomarkers for acute kidney injury

Patent metadata

Field	Value
Publication number	US-9410968-B2
Application number	US-201214006991-A
Country	US
Kind code	B2
Filing date	Mar 29, 2012
Priority date	Apr 4, 2011
Publication date	Aug 9, 2016
Grant date	Aug 9, 2016

Abstract

Disclosed is an animal model that can be used, among other things, to generate biomarkers for the prognosis and/or diagnosis of acute kidney injury, more specifically sepsis-induced acute kidney injury. Disclosed are three such biomarkers. The disclosure specifically relates to human chitinase 3-like protein 1 for use as a biomarker.

First claim

The invention claimed is:

1. A composition comprising:
binding molecules to chitinase 3-like protein 1, and
urine from a subject;
wherein the subject is selected from the group consisting of:
a critically ill subject in intensive care, a subject suffering from septic shock, a subject post-operative from cardiac surgery, a critically ill subject suffering from burns, and/or trauma, and a subject who has ingested nephrotoxic drugs or radiocontrast agents.

2. The composition of claim 1 , wherein the chitinase-3-like protein 1 comprises SEQ ID NO:1.

Assignees

• Meyer Evelyne
• Maddens Bert
• Univ Gent

Inventors

• Meyer Evelyne
• Maddens Bert

Classifications

• G01N2800/347

  Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy · CPC title

• G01N2333/924

  acting on glycosyl compounds (3.2) · CPC title

• G01N33/6893 Primary

  related to diseases not provided for elsewhere · CPC title