Immunogenic composition
US-2024238398-A1 · Jul 18, 2024 · US
Vaccines against Toxoplasma gondii
US9408899B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9408899-B2 |
| Application number | US-201113823668-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 3, 2011 |
| Priority date | Nov 4, 2010 |
| Publication date | Aug 9, 2016 |
| Grant date | Aug 9, 2016 |
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- Title
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- Abstract
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- First independent claim
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Abstract
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Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is Toxoplas gondii.
First claim
Opening claim text (preview).
The invention claimed is: 1. A composition comprising a plurality of peptides, wherein the plurality of peptides comprises a first peptide with the amino acid sequence KSFKDILPK (SEQ ID NO: 4), a second peptide with the amino acid sequence RSFKDLLKK (SEQ ID NO: 6), and a third peptide with the amino acid sequence AKFVAAWTLKAAA (SEQ ID NO: 7), wherein the plurality of peptides are linked to form a chimeric polypeptide. 2. The composition of claim 1 , wherein the composition comprises an oil-in-water emulsion that includes a synthetic adjuvant monophosphorvl lipid A (MLA). 3. The composition of claim 1 wherein the plurality of peptides further comprises one or more of AVVSLLRLLK (SEQ ID NO:23), STFWPCLLR (SEQ ID NO:21), and SSAYVFSVK (SEQ ID NO:22). 4. The composition of claim 3 , further comprising an adjuvant. 5. The composition of claim 3 wherein the plurality of peptides further comprises one or more of FLSLSLLVI (SEQ ID NO: 11) FMIAFISCFA (SEQ ID NO: 12), FVIFACNFV (SEQ ID NO: 16), FMIVSISLY (SEQ ID NO: 13), FLLGLLVHV (SEQ ID NO: 15), FLTDYIPGA (SEQ ID NO: 14), ITMGSLFFV (SEQ ID NO: 17), GLAAAVYAV (SEQ ID NO: 18), VLLPVLFGV (SEQ ID NO: 20), FAAAFFPAV (SEQ ID NO: 19), VVFVVFMGV (SEQ ID NO: 1), FMGVLVNSL (SEQ ID NO: 2), FLVPFVVFL (SEQ ID NO: 3), AMLTAFFLR (SEQ ID NO: 5), LPOFATAAT (SEQ ID NO: 8), VPFVVFLVA (SEQ ID NO: 9), and HF10 (HPGSVNEFDF (SEQ ID NO: 10)). 6. The composition of claim 5 , further comprising an adjuvant. 7. The composition of claim 1 wherein the plurality of peptides further comprises one or more of FLSLSLLVI (SEQ ID NO: 11), FMIAFISCFA (SEQ ID NO: 12), FVIFACNFV (SEQ ID NO: 16), FMIVSISLV (SEQ ID NO: 13), FLLGLLVHV (SEQ ID NO: 15), FLTDYIPGA (SEQ ID NO: 14), ITMGSLFFV (SEQ ID NO: 17), GLAAAVVAV (SEQ ID NO: 18), VLLPVLFGV (SEQ ID NO: 20), FAAAFFPAV (SEQ ID NO: 19), VVFVVFMGV (SEQ ID NO: 1), FMGVLVNSL (SEQ ID NO: 2), FLVPFVVFL (SEQ ID NO: 3), AMLTAFFLR (SEQ ID NO: 5), LPQFATAAT (SEQ ID NO: 8), VPFVVFLVA (SEQ ID NO: 9), and HF10 (HPGSVNEFDF (SEQ ID NO: 10)). 8. The composition of claim 7 , further comprising an adjuvant. 9. The composition of claim 1 further comprising an adjuvant.
Assignees
Inventors
Classifications
- A61K39/002Primary
Protozoa antigens · CPC title
Lipopolysaccharides; Lipid A; Monophosphoryl lipid A · CPC title
Proteins · CPC title
Patent family
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9408899B2 cover?
- Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is Toxoplas gondii.
- Who is the assignee on this patent?
- Mcleod Rima, Tan Tze Guan, Alexander Jeffery L, and 8 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/002. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 09 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).