Oral administration of melanin for protection against radiation

Patent metadata

Field	Value
Publication number	US-9408882-B2
Application number	US-201214005601-A
Country	US
Kind code	B2
Filing date	Mar 15, 2012
Priority date	Mar 18, 2011
Publication date	Aug 9, 2016
Grant date	Aug 9, 2016

Abstract

Methods and compositions are provided for alleviating and/or preventing one or more side effects associated with exposure to radiation in a subject exposed to radiation or at risk for exposure to radiation comprising oral administration to the subject of an amount of an edible source of melanin effective to alleviate a side effect associated with radiation.

First claim

What is claimed is:

1. A method for alleviating one or more side effects associated with exposure to radiation in a subject in need thereof comprising orally administering to the subject an effective amount of a drinkable suspension containing at least 250 mg of a dried powdered edible source of melanin in a volume of at least 10 mL, wherein the edible source of melanin comprises Auricularia auricular - judae.

2. A method for increasing the survival rate of a plurality of subjects exposed to an amount of radiation likely to kill the plurality of subjects comprising orally administering to each of the plurality of subjects an effective amount of a drinkable suspension comprising 250 mg of a dried powdered edible source of melanin in a volume of at least 10 mL, wherein the edible source of melanin comprises Auricularia auricular - judae.

3. The method of claim 1 , wherein edible source of melanin is administered to the subject, or to the subjects, in an amount equivalent to at least 8 mg of purified melanin per kg of body weight of the subject.

4. The method of claim 1 , wherein the edible source of melanin comprising Auricularia auricular - judae comprises at least 10% melanin per dry weight of the biological source.

5. The method of claim 1 , wherein the Auricularia auricular - judae is grown in the presence of a melanin precursor selected from is one or more of L-dopa (3,4-dihydroxyphenylalanin), D-dopa, catechol, 5-hydroxyindole, tyramine, dopamine, tyrosine, cysteine, m-aminophenol, o-aminophenol, p-aminophenol, 4-aminocatechol, 2-hydroxyl-1,4-naphthaquinone, 4-metholcatechol, 3,4-dihydroxynaphthalene, gallic acid, resorcinol, 2-chloroaniline, p-chloroanisole, 2-amino-p-cresol, 4,5-dihydroxynaphthalene, 1,8-dihydroxynaphthalene, 2,7-disulfonic acid, o-cresol, m-cresol, and p-cresol.

6. The method of claim 1 , wherein the edible source of melanin is administered in an edible substance of at least 80 mg of edible substance per kg of body weight of the subject.

7. The method of claim 6 , wherein the edible source of melanin is administered as at least 80 mg of dry mushrooms per kg of body weight of the subject.

8. The method of claim 1 , wherein an internal organ of the subject is protected from radiation.

9. The method of claim 8 , wherein the organ that is protected is one or more organ selected from the group consisting of bone marrow, liver, spleen, kidneys, lungs, and gastrointestinal tract.

10. The method of claim 1 , wherein the side effect associated with radiation is one or more of acute-nature nausea, vomiting, abdominal pain, diarrhea, dizziness, headache, fever, cutaneous radiation syndrome, low blood cell count, infection due to low white blood cells, bleeding due to low platelets, anemia due to low red blood cells, weight loss or death.

11. The method of claim 1 , wherein the method increases the subject's chance of survival following exposure to radiation.

12. The method of claim 1 , wherein the dose of radiation received by the subject would be lethal to the subject in the absence of radioprotection.

13. The method of claim 1 , wherein the radiation comprises ionizing radiation.

14. The method of claim 13 , wherein the radiation comprises one or more of gamma radiation, x-ray radiation, solar radiation, cosmic radiation, electromagnetic radiation, bremsstrahlung radiation, ultraviolet radiation, and particulate radiation.

15. The method of claim 1 , wherein the radiation is from a man-made source of radiation.

Assignees

• Dadachova Ekaterina
• Casadevall Arturo
• Albert Einstein College Medicine Inc

Inventors

• Dadachova Ekaterina
• Casadevall Arturo

Classifications

• A61P39/00

  General protective or antinoxious agents · CPC title

• A61P7/04

  Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title

• A61P7/06

  Antianaemics · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P1/08

  for nausea, cinetosis or vertigo; Antiemetics · CPC title