Pharmaceutical composition comprising guttiferone F for the treatment of prostate cancer

Patent metadata

Field	Value
Publication number	US-9408811-B2
Application number	US-201414333524-A
Country	US
Kind code	B2
Filing date	Jul 17, 2014
Priority date	Jul 18, 2013
Publication date	Aug 9, 2016
Grant date	Aug 9, 2016

Abstract

Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound of formula (I):

More particularly, it relates to said anti-prostate cancer compound that can be isolated from Garcinia esculenta or chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.

First claim

What is claimed is:

1. A method for inhibiting prostate cancer tumor growth in a human, comprising administering to said human a therapeutically effective amount of a pharmaceutical composition comprising a compound of formula (I):

and a pharmaceutically acceptable carrier, excipient and/or adjuvant.

2. The method of claim 1 , wherein said therapeutically effective amount is equal to or greater than 0.81 mg/kg to body weight of said human.

3. The method of claim 1 , wherein said therapeutically effective amount is from 0.81 mg/kg to 2.40 mg/kg to body weight of said human.

4. The method of claim 1 , wherein said therapeutically effective amount is from 0.81 mg/kg to 1.20 mg/kg to body weight of said human.

5. The method of claim 1 , wherein said pharmaceutical composition is administered to said human via one or more routes selected from the group consisting of subcutaneous, intratumoral, intraperitoneal, intravenous and oral.

6. The method of claim 1 , wherein said pharmaceutical composition is administered at least once every two days to said human.

7. The method of claim 1 , wherein said pharmaceutical composition is administered daily to said human.

8. The method of claim 1 , wherein said human is under caloric restriction.

Assignees

• Univ Hong Kong Baptist Univ

Inventors

• Xu Hongxi
• Li Xin
• Zhang Hong
• Lao Yuanzhi
• Tan Hongsheng
• Wang Xiaoyu
• Chen Kaixian
• Bian Zhaoxiang
• Yang Dajian
• Chen Shilin
• Lu Aiping
• Chan Albert Sun Chi

Classifications

• A61K2236/00

  Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine · CPC title

• A61K31/122 Primary

  having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin · CPC title

• A61K36/38

  Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort · CPC title