Systems and methods for signal processing in molecular imaging
US-2024013454-A1 · Jan 11, 2024 · US
US9405024B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9405024-B2 |
| Application number | US-201414339489-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 24, 2014 |
| Priority date | May 28, 2009 |
| Publication date | Aug 2, 2016 |
| Grant date | Aug 2, 2016 |
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A radiation detector module for use in a time-of-flight positron emission tomography (TOF-PET) scanner generates a trigger signal indicative of a detected radiation event. A timing circuit including a first time-to-digital converter (TDC) and a second TDC is configured to output a corrected timestamp for the detected radiation event based on a first timestamp determined by the first TDC and a second timestamp determined by the second TDC. The first TDC is synchronized to a first reference clock signal and the second TDC is synchronized to a second reference clock signal, the first and second reference clock signals being asynchronous.
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Having thus described the preferred embodiments, the invention is now claimed to be: 1. A method for associating a time index to a detected event, including: using a first time-to-digital converter (TDC) to associate time indices to detected events; if a detected event occurs during a metastable phase of the first TDC, using at least a second TDC to associate a time index to the detected event; and providing the time indices to detector circuitry. 2. The method according to claim 1 , wherein the metastable phases of the first and second TDCs are non-synchronous. 3. The method according to claim 1 , wherein one of the first and second TDCs has a higher temporal resolution than the other TDC. 4. The method according to claim 1 , wherein the second TDC has a metastable state, the metastable states of the first and second TDCs being temporally offset. 5. The method according to claim 1 , wherein the second TDC has a metastable state, the metastable states of the first and second TDCs being non-concurrent. 6. The method according to claim 1 , further including: with the first TDC, outputting a first reference clock signal. 7. The method according to claim 6 , further including: with the second TDC, outputting a second reference clock signal. 8. The method according to claim 7 , wherein the first and second reference clock signals transition between high and low states, the transitions of the first and second clock signals being non-synchronous. 9. The method according to claim 8 , wherein the time indices are provided based on the transitions. 10. The method according to claim 1 , further including: outputting a first time stamp based on the time indices associated to the detected events by the first TDC; outputting a second time stamp based on the time indices associated to the detected events by the second TDC; generating a corrected time stamp based on at least one of the first and second time stamps. 11. The method according to claim 10 , wherein the corrected time stamp is based on the earliest of the first and second time stamps. 12. The method according to claim 1 , further including: with the detector circuitry, generating a time stamp for the detected event based on the time indices associated with the detected events detected by the first and second TDCs. 13. A method of associated a time index to a detected event, comprising: with a first TDC which has metastable phases, associating a first time index with the detected event; with a second TDC which has metastable phases, associating a second time index with the detected event, the metastable phases of the first and second TDCs being non-synchronous. 14. The method according to claim 13 , further including: with a circuit, generating a time stamp for the detected event based on the first and second time indices. 15. An apparatus for associating a time index to a detected event comprising: a first TDC configured to associate a first time index to the detected event; a second TDC configured to associate a second time index with the detected event if the detected event occurs during a metastable state of the first TDC; and a circuit configured to receive the first and second time indices. 16. The apparatus according to claim 15 , wherein the first and second TDCs are configured to have non-synchronous metastable states. 17. The apparatus according to claim 16 , wherein the circuit is configured to generate a time stamp for the detected event based on the first and second time indices. 18. The apparatus according to claim 17 , wherein the circuit is configured to generate the time stamp based on the earlier of the time indices. 19. The apparatus according to claim 15 , wherein the first TDC is configured to generate a first reference clock signal and the second TDC is configured to generate a second reference clock signal, the first and second reference clock signals being temporally offset. 20. The apparatus according to claim 15 , wherein the first TDC is configured to generate a first reference clock signal that alternately transitions between a high state and a low state; the second TDC is configured to generate a second reference clock signal that alternately transitions between a high state and a low state; and the transitions of the first and second clock signals are temporally displaced.
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