Microfluidic bubble logic devices

Patent metadata

Field	Value
Publication number	US-9404835-B2
Application number	US-201414481855-A
Country	US
Kind code	B2
Filing date	Sep 9, 2014
Priority date	May 2, 2005
Publication date	Aug 2, 2016
Grant date	Aug 2, 2016

Abstract

Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, sample collectors, and printers have been designed.

First claim

What is claimed is:

1. A platform for collection of samples, comprising:
a fluidic bubble logic collection circuit, comprising:
an extraction circuit that collects at least one sample from a stream of material; and
a bubble generator that encapsulates the collected sample inside a bubble or droplet of inert material dispersed in an immiscible fluid;

at least one fluidic bubble logic memory element for storing the collected sample for analysis; and
a fluidic bubble logic routing circuit for routing the collected sample from the collection circuit to the memory element.

2. The platform of claim 1 , wherein the fluidic bubble logic collection circuit, the at least one fluidic bubble logic memory element, and the fluidic bubble logic routing circuit are contained on a single chip.

3. The platform of claim 1 , further comprising at least a second fluidic bubble logic memory element for storing information associated with the collected sample as an encoded bubble or droplet pattern.

4. The platform of claim 1 , further comprising a sorter for removing unwanted collected samples and empty droplets or bubbles.

5. The platform of claim 1 , the sorter further comprising a bubble annihilator.

6. The platform of claim 1 , further comprising a fluidic bubble logic device for screening the collected sample according to a detected or measured property of the collected sample.

7. The platform of claim 1 , further comprising a detection or measurement device for detecting or measuring a property of the collected sample.

8. The platform of claim 7 , further comprising a fluidic bubble logic device for screening the collected sample according to the detected or measured property.

9. The platform of claim 1 , wherein samples are collected from the stream of material by the fluidic bubble logic collection circuit at a user-defined rate.

10. The platform of claim 1 , the fluidic bubble logic memory element comprising:
a logic circuit configured to receive as an input, from the bubble logic fluidic routing circuit, a droplet or bubble containing the collected sample, and to store the received droplet or bubble, the logic circuit comprising:
a configuration of channels having interconnections, the channels and channel interconnections being configured so that the direction of flow, through the channels, of the droplet or bubble containing the collected sample is controlled by at least one of the group selected from: a resistive or constrictive force caused by interaction between the droplet or bubble and the geometry of the channels, a resistive or constrictive force caused by interaction between the droplet or bubble and the configuration of the channel interconnections, and the interaction between the droplet or bubble and other bubbles;
at least one channel input for accepting the droplet or bubble containing the collected sample into the configuration of interconnected channels; and
at least one channel output for discharging the droplet or bubble containing the collected sample from the configuration of interconnected channels.

11. The platform of claim 1 , the fluidic bubble logic routing circuit comprising:
a logic circuit configured to receive, as an input from the fluidic bubble logic collection circuit, a droplet or bubble containing the collected sample, and to route the received droplet or bubble to the bubble logic memory element, the logic circuit comprising:
a configuration of channels having interconnections, the channels and channel interconnections being configured so that the direction of flow, through the channels, of the droplet or bubble containing the collected sample is controlled by at least one of the group selected from: a resistive or constrictive force caused by interaction between the droplet or bubble and the geometry of the channels, a resistive or constrictive force caused by interaction between the droplet or bubble and the configuration of the channel interconnections, and the interaction between the droplet or bubble and other bubbles;

at least one channel input for accepting the droplet or bubble containing the collected sample into the configuration of interconnected channels; and
at least one channel output for discharging the droplet or bubble containing the collected sample from the configuration of interconnected channels to the memory element.

12. The platform of claim 1 , the fluidic bubble logic routing circuit comprising cascaded fluidic logic circuits.

13. The platform of claim 1 , wherein the fluidic bubble logic memory element for storing the collected sample is a bistable memory element.

14. The platform of claim 1 , the fluidic bubble logic collection circuit comprising a generator configured to encapsulate the collected sample in the bubble or droplet.

Assignees

• Prakash Manu
• Gershenfeld Neil
• Massachusetts Inst Technology

Inventors

• Prakash Manu
• Gershenfeld Neil

Classifications

• Y10T137/2076

  Utilizing diverse fluids · CPC title

• Y10T436/25

  including sample preparation · CPC title

• Y10T137/87153

  Plural noncommunicating flow paths · CPC title

• Y10T137/9247

  With closure · CPC title

• G01N1/2035 Primary

  by deviating part of a fluid stream, e.g. by drawing-off or tapping · CPC title