Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators

Patent metadata

Field	Value
Publication number	US-9402861-B2
Application number	US-201213603125-A
Country	US
Kind code	B2
Filing date	Sep 4, 2012
Priority date	Mar 2, 2010
Publication date	Aug 2, 2016
Grant date	Aug 2, 2016

Abstract

Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.

First claim

What is claimed is:

1. A composition comprising:
a polymeric chelator comprising a plurality of polyamine polymer backbone chains and one or more chelators, wherein the polyamine polymer backbone chains are polyallylamine or polylysine;
wherein the one or more chelators are covalently coupled to one or more primary amines, respectively, of at least one of the plurality of polyamine polymer backbone chains through one or more amide bonds, respectively, wherein each of the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free; and
wherein the plurality of polyamine polymer backbone chains are cross-linked to one another independent of any cross-linking that may result from interactions with the one or more chelators.

2. The composition of claim 1 , wherein the polymeric chelator is injectable.

3. The composition of claim 1 , wherein the polymeric chelator is a hydrogel.

4. The composition of claim 1 , wherein the polymeric chelator is ingestible.

5. The composition of claim 1 , wherein the one or more chelators are capable of chelating a metal.

6. The composition of claim 1 , wherein the one or more chelators are capable of chelating a heavy metal.

7. The composition of claim 1 , wherein the one or more chelators are capable of chelating aluminum, arsenic, cadmium, chromium, copper, iron, lead, manganese, mercury, or combination thereof.

8. The composition of claim 1 , wherein the one or more chelators are a derivative of a metal chelator.

9. The composition of claim 1 wherein each of the one or more chelators is derived from 2,3 dihydroxybenzoic acid.

10. The composition of claim 1 wherein the molar ratio of A to B is from about 0.07 to about 0.17, wherein A is chelators covalently coupled to primary amines, and wherein B is total amines of the polymeric chelator.

11. The composition of claim 1 wherein the molar ratio of A to B is from about 0.03 to about 0.22, wherein A is chelators covalently coupled to primary amines, and wherein B is total amines of the polymeric chelator.

Assignees

• Berkland Cory
• Mohammadi Zahra
• Univ Kansas

Inventors

• Berkland Cory
• Mohammadi Zahra

Classifications

• A61K47/595

  Polyamides, e.g. nylon (polyamino acids A61K47/62) · CPC title

• C08F126/02

  by a single or double bond to nitrogen · CPC title

• A61K47/547 Primary

  Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent · CPC title

• C08G2210/00

  Compositions for preparing hydrogels · CPC title

• A61K47/58

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin · CPC title