Method and apparatus for providing dynamic multi-stage signal amplification in a medical device

Patent metadata

Field	Value
Publication number	US-9402584-B2
Application number	US-201514596759-A
Country	US
Kind code	B2
Filing date	Jan 14, 2015
Priority date	Apr 14, 2007
Publication date	Aug 2, 2016
Grant date	Aug 2, 2016

Abstract

Methods and apparatus for providing multi-stage signal amplification in a medical telemetry system are provided.

First claim

What is claimed is:

1. A method of processing signals from an analyte sensor, comprising:
coupling a first amplifier to a second amplifier and a signal source;
comparing signals at an output terminal of the second amplifier to a predetermined threshold value; and
processing a signal associated with the signals at the second amplifier output terminal when another signal at the second amplifier output terminal exceeds the predetermined threshold value.

2. The method of claim 1 , wherein the first amplifier includes a transimpedance amplifier.

3. The method of claim 1 , wherein the first amplifier includes an inverting input terminal.

4. The method of claim 3 , further including coupling a reference signal source to a noninverting input terminal of the first amplifier.

5. The method of claim 1 , wherein a first output signal from the first amplifier is a predetermined ratio of a second output signal from the second amplifier.

6. The method of claim 5 , wherein the first output signal is associated with a signal from the signal source.

7. The method of claim 5 , wherein the first output signal and the second output signal are associated with a monitored analyte level.

8. The method of claim 1 , further including configuring the signal source to receive one or more signals associated with a monitored analyte level from the analyte sensor.

9. The method of claim 1 , further including operatively coupling the signal source to a glucose sensor.

10. The method of claim 9 , wherein the glucose sensor comprises a plurality of electrodes including a working electrode, wherein the working electrode comprises a glucose-responsive enzyme and a mediator, wherein at least one of the glucose-responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and wherein at least one of the glucose-responsive enzyme and the mediator is crosslinked with the polymer.

11. An apparatus, comprising:
a first amplifier operatively coupled to a signal source;
a second amplifier operatively coupled to the first amplifier; and
a processing unit operatively coupled to one or more of the first amplifier, and the second amplifier, the processing unit configured to compare signals at an output terminal of the second amplifier to a predetermined threshold value, and configured to process a signal associated with the signals at the second amplifier output terminal when another signal at the second amplifier output terminal exceeds the predetermined threshold value.

12. The apparatus of claim 11 , wherein the first amplifier includes a transimpedance amplifier.

13. The apparatus of claim 11 , wherein the first amplifier includes an inverting input terminal.

14. The apparatus of claim 13 , further including a reference signal source operatively coupled to a noninverting input terminal of the first amplifier.

15. The apparatus of claim 11 , wherein a first output signal from the first amplifier is a predetermined ratio of a second output signal from the second amplifier.

16. The apparatus of claim 15 , wherein the first output signal is associated with a signal from the signal source.

17. The apparatus of claim 15 , wherein the first output signal and the second output signal are associated with a monitored analyte level.

18. The apparatus of claim 11 , wherein the signal source is further configured to receive one or more signals associated with a monitored analyte level from an analyte sensor.

19. The apparatus of claim 11 , wherein the signal source is operatively coupled to a glucose sensor.

20. The apparatus of claim 19 , wherein the glucose sensor comprises a plurality of electrodes including a working electrode, wherein the working electrode comprises a glucose-responsive enzyme and a mediator, wherein at least one of the glucose-responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and wherein at least one of the glucose-responsive enzyme and the mediator is crosslinked with the polymer.

Assignees

• Abbott Diabetes Care Inc

Inventors

• Fennell Martin J

Classifications

• A61B5/7225 Primary

  Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation (input circuits for detecting, measuring, or recording bioelectric or biomagnetic signals A61B5/30; specific diagnostic methods using bioelectric or biomagnetic signals A61B5/316) · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61M5/1723

  using feedback of body parameters, e.g. blood-sugar, pressure (measurement of body parameters A61B5/00) · CPC title

• A61B5/002

  Monitoring the patient using a local or closed circuit, e.g. in a room or building (A61B5/0017 takes precedence) · CPC title

• A61B5/7475

  User input or interface means, e.g. keyboard, pointing device, joystick · CPC title