Synthetic route to pactamycin and pactamycin analogs

US9399652B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9399652-B2
Application numberUS-201414758110-A
CountryUS
Kind codeB2
Filing dateJan 23, 2014
Priority dateJan 24, 2013
Publication dateJul 26, 2016
Grant dateJul 26, 2016

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Abstract

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Methods and intermediates useful for making compounds of Formula (I) are described, including a general method of making an alpha, beta-diamino ketone by reacting an imine with a 2-amino-substituted 1,3-dicarbonyl in a Mannich addition reaction to produce said alpha,beta-diamino ketone.

First claim

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That which is claimed is: 1. A compound of Formula IX: wherein: R 8 is H, hydroxy, silyloxy, acyloxy, or alkoxy; and R 9 is —N(R c R d ), —OR c , or —SR c , where R c and R d are each independently selected alkyl, aryl, or heteroaryl, or R c and R d together form an alkylene bridge; and X is a protecting group. 2. A method of making a co…

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What does patent US9399652B2 cover?
Methods and intermediates useful for making compounds of Formula (I) are described, including a general method of making an alpha, beta-diamino ketone by reacting an imine with a 2-amino-substituted 1,3-dicarbonyl in a Mannich addition reaction to produce said alpha,beta-diamino ketone.
Who is the assignee on this patent?
Univ North Carolina Chapel Hill
What technology area does this patent fall under?
Primary CPC classification C07F7/1804. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Jul 26 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).