System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings
US-9008765-B2 · Apr 14, 2015 · US
US9399124B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9399124-B2 |
| Application number | US-201414223790-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 24, 2014 |
| Priority date | Dec 7, 2009 |
| Publication date | Jul 26, 2016 |
| Grant date | Jul 26, 2016 |
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Embodiments provide apparatus and methods for producing markings in the skin. One embodiment provides an apparatus for marking the skin comprising a housing and reservoir for storing a skin colorant. An electrode is positioned within the housing so as to be electrically coupled to the colorant in the reservoir and is configured to be coupled to a current source and return electrode. A colorant applicator having at least one fluid pathway is coupled to a housing distal end. The applicator proximal end is positioned such that the fluid pathway is coupled with the reservoir. The applicator distal end applies colorant to the skin surface through the fluid pathway as the applicator is moved across the skin. The electrode delivers current from the current source to the skin to transport charged pigment elements of the colorant into the skin using an electromotive driving force to produce a marking in the skin.
Opening claim text (preview).
What is claimed is: 1. An apparatus for producing markings in skin, the apparatus comprising: a reservoir for storage of a skin colorant; a colorant applicator, the applicator having a proximal and distal end and at least one fluid pathway, the proximal end of the colorant applicator being positioned within the reservoir such that the at least one fluid pathway is coupled with the reservoir, the distal end of the colorant applicator being configured to apply colorant from the reservoir to a skin surface through the at least one fluid pathway as the applicator is moved across the skin; an electrode electrically coupled to a current source and a return electrode, the electrode positioned so that a portion of the electrode extends out of the reservoir and a distal portion of the electrode extends into the reservoir without contacting the applicator, so as to immerse the distal portion in the colorant and electrically couple the electrode to the colorant; and wherein the electrode is configured to deliver current to the skin to transport charged pigment elements of the colorant into the skin using an electromotive driving force to produce a marking in the skin from the pigment elements. 2. The apparatus of claim 1 , wherein the driving force is an iontophoretic force. 3. The apparatus of claim 1 , wherein the colorant comprises charged nano-particles including a pigment compound. 4. The apparatus of claim 1 , wherein the current is alternating current. 5. The apparatus of claim 1 , wherein the current comprises a DC component and an AC component. 6. The apparatus of claim 5 , wherein the AC component is configured to break down a capacitive charge buildup in skin tissue. 7. The apparatus of claim 1 , wherein the current is modulated to control a depth of penetration of colorant into the skin. 8. The apparatus of claim 1 , wherein the current is modulated to control a perception of pain in the skin of a person receiving a marking. 9. The apparatus of claim 8 , wherein the current is modulated to minimize a perception of pain in the person receiving the marking. 10. The apparatus of claim 1 , further comprising a housing, at least a portion of which is configured to be held in a hand of a user. 11. The apparatus of claim 10 , wherein the housing has a proximal and distal end and the colorant applicator is coupled to the distal end of the housing. 12. The apparatus of claim 11 , wherein the colorant applicator is slidable across the skin surface to deliver colorant to the skin surface. 13. The apparatus of claim 11 , wherein the colorant comprises a magnetic material. 14. The apparatus of claim 13 , wherein the magnetic material and the marking are configured to allow the marking to be read by a magnetic reading device passed above the skin surface containing the marking. 15. The apparatus of claim 14 , wherein the marking provides indicia indicating whether a limb is to be operated on and/or to not be operated on. 16. The apparatus of claim 13 , wherein the magnetic material comprises at least one of a ferrite material, a hematite, a nano-particle, or a hematite nano-particle. 17. A method for marking the skin using iontophoresis, the method comprising: applying a colorant including an ionizable pigment compound to a skin surface using a colorant applicator, the applicator having a proximal and distal end and at least one fluid pathway, the proximal end of the colorant applicator being positioned within a reservoir for storage of a skin colorant such that the at least one fluid pathway is coupled with the reservoir, the distal end of the colorant applicator being configured to apply colorant from the reservoir to a skin surface through the at least one fluid pathway as the applicator is moved across the skin; and delivering a current to the skin and the colorant to ionize the colorant and transport the colorant into the skin using an electromotive driving force produced with an electrode electrically coupled to a current source and a return electrode, the electrode positioned so that a portion of the electrode extends out of the reservoir and a distal portion of the electrode extends into the reservoir without contacting the applicator, so as to immerse the distal portion in the colorant and electrically couple the electrode to the colorant. 18. The method of claim 17 , further comprising modulating the current to control a depth of penetration of colorant into the skin. 19. The method of claim 17 , further comprising modulating the current to control a perception of pain in the skin of a person receiving a marking. 20. The method of claim 17 , further comprising sliding the colorant applicator across the skin surface to deliver colorant to the skin surface.
for improving the appearance of the skin, e.g. facial toning or wrinkle treatment · CPC title
for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body (electrodes for external use A61N1/0428) · CPC title
Tattooing apparatus with incorporated liquid feeding device · CPC title
Skin · CPC title
Material of the electrode · CPC title
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