Sealant storage, preparation, and delivery systems and related methods

Patent metadata

Field	Value
Publication number	US-9398913-B2
Application number	US-201313773206-A
Country	US
Kind code	B2
Filing date	Feb 21, 2013
Priority date	Aug 24, 2012
Publication date	Jul 26, 2016
Grant date	Jul 26, 2016

Abstract

A bioadhesive sealant storage and preparation system may comprise a plurality of containers and an adapter. The plurality of containers may comprise a first container having a first bioadhesive sealant component therein, and a second container having a second bioadhesive sealant component therein. The adapter may comprise a manifold comprising a plurality of channels formed therein, an inlet region sized and configured to receive the plurality of containers and facilitate fluid communication between each container of the plurality of containers and a respective channel of the plurality of channels, and an outlet region sized and configured to receive a syringe and provide fluid communication between the syringe and the plurality of channels.

First claim

What is claimed is:

1. A bioadhesive sealant storage and preparation system, comprising:
a plurality of containers, the plurality of containers comprising:
a first container having a first bioadhesive sealant component therein;
a second container having a second bioadhesive sealant component therein;

a coupling device coupling the plurality of containers together, the coupling device comprising a protrusion;
an adapter movable relative to the coupling device, the adapter comprising:
a manifold comprising a plurality of channels formed therein;
an inlet region configured to connect to the plurality of containers and facilitate fluid communication between each container of the plurality of containers and a respective channel of the plurality of channels, the inlet region comprising a receptacle, the plurality of containers being movable between a first position at which the containers are connected to the receptacle and a second position at which the containers are connected to the receptacle, the plurality of containers being biased to the first position;
a first recess formed in the receptacle and a second recess formed in the receptacle, wherein the protrusion of the coupling device is seated in the first recess when the plurality of containers are in the first position and the protrusion is seated in the second recess when the plurality of containers are in the second position;
an outlet region configured to connect to at least one syringe and provide fluid communication between the at least one syringe and the plurality of channels.

2. The bioadhesive sealant storage and preparation system of claim 1 , wherein the receptacle is configured to release the plurality of containers to a second position in response to an applied force, wherein the plurality of containers are separated from the manifold and are prevented from being in fluid communication with the plurality of channels when positioned in the first position, wherein the plurality of containers are each proximate to the manifold and are each in fluid communication with a respective channel of the plurality of channels when positioned in the second position.

3. The bioadhesive sealant storage and preparation system of claim 2 , further comprising:
a plurality of needles positioned at the inlet region of the adapter, each needle of the plurality of needles in fluid communication with a respective channel of the plurality of channels;
wherein each container of the plurality of containers comprises a septum.

4. The bioadhesive sealant storage and preparation system of claim 3 , wherein the at least one syringe comprises a double barrel syringe sized and configured to couple to the outlet region of the adapter, a first barrel of the double barrel syringe comprising a third bioadhesive sealant component stored therein, the double barrel syringe configured to receive the first bioadhesive sealant component of the first container into the first barrel through a channel of the plurality of channels of the manifold, to receive the second bioadhesive sealant component of the second container into a second barrel through another channel of the plurality of channels of the manifold.

5. The bioadhesive sealant storage and preparation system of claim 4 :
wherein the third bioadhesive sealant component comprises at least one of polyethylene glycol and a thiol in a powder form;
wherein the first bioadhesive sealant component of the first container comprises an acrylate in liquid form;
wherein the second bioadhesive sealant component of the second container comprises an activator.

6. The bioadhesive sealant storage and preparation system of claim 2 , wherein the first bioadhesive sealant component of the first container is stored at a first pressure and the second bioadhesive sealant component of the second container is stored at a second pressure, the second pressure being greater than the first pressure.

7. The bioadhesive sealant storage and preparation system of claim 6 , wherein the first bioadhesive sealant component of the first container is stored in a vacuum condition.

8. The bioadhesive sealant storage and preparation system of claim 7 , wherein the first bioadhesive sealant component of the first container comprises a powder and wherein the second bioadhesive sealant component of the second container comprises a liquid.

9. The bioadhesive sealant storage and preparation system of claim 8 :
wherein a first channel of the plurality of channels is positioned and configured for fluid communication with the first bioadhesive sealant component of the first container and a second channel of the plurality of channels is positioned and configured for fluid communication with the second bioadhesive sealant component of the second container when the plurality of containers are positioned in the second position;
wherein the first channel is in fluid communication with the second channel.

10. The bioadhesive sealant storage and preparation system of claim 9 , wherein the at least one syringe comprises a double barrel syringe sized and configured to couple to the outlet region of the adapter, to receive the first bioadhesive sealant component of the first container and the second bioadhesive sealant component of the second container into a first barrel through a channel of the plurality of channels of the manifold, and to receive a third bioadhesive sealant component into a second barrel through another channel of the plurality of channels of the manifold.

11. The bioadhesive sealant storage and preparation system of claim 8 , wherein the first bioadhesive sealant component of the first container comprises at least one of polyethylene glycol and a thiol, wherein the second bioadhesive sealant component of the second container comprises an acrylate.

12. The bioadhesive sealant storage and preparation system of claim 1 :
wherein the plurality of containers further comprises a third container having a third bioadhesive sealant component therein;
wherein the first container and the second container are positioned and configured within a receptacle of the adapter to maintain the first bioadhesive sealant component and the second bioadhesive sealant component separated for storage and to allow the mixing of the first bioadhesive sealant component and the second bioadhesive sealant component in response to an applied force.

13. The bioadhesive sealant storage and preparation system of claim 12 , wherein the adapter further comprises a movable barrier positioned between the plurality of containers and the manifold, the movable barrier sized and configured to prevent fluid communication between the plurality of containers and the plurality of channels of the manifold when a force is applied and the movable barrier is positioned in a first position and to allow fluid communication between the plurality of containers and the plurality of channels of the manifold when the force is applied and the movable barrier is positioned in a second position.

14. The bioadhesive sealant storage and preparation system of claim 1 , further comprising:
a syringe coupled to the outlet region of the adapter;
a pouch comprising a barrier separating a first region of the pouch from a second region of the pouch;
wherein the syringe is located in the first region of the pouch and the plurality of containers are located within the second region of the pouch;
wherein the first region of the pouch is sterile.

15. A tissue puncture closure system, comprising:
a syringe;
a bioadhesive sealant storage and preparation system, comprising:
a plurality of containers, the plurality of containers

Assignees

• St Jude Medical Puerto Rico

Inventors

• Tegels Zachary J
• Terwey Russell D
• White Troy T
• Mcglinch Timothy M
• Kaeferlein Bernhard
• Parsonage Edward E
• Escobar Martha

Classifications

• A61B2017/0065

  the implement being an adhesive · CPC title

• A61B2017/00495

  for two-component glue · CPC title

• A61B17/08 Primary

  Wound clamps {or clips, i.e. not or only partly penetrating the tissue (suture bridges A61B17/0466); Devices for bringing together the edges of a wound} · CPC title

• A61B17/00491

  Surgical glue applicators · CPC title

• A61B17/0057 Primary

  Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect (sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009) · CPC title