Controlled slew rate transition for electrochemical analysis

Patent metadata

Field	Value
Publication number	US-9395332-B2
Application number	US-201313920117-A
Country	US
Kind code	B2
Filing date	Jun 18, 2013
Priority date	Dec 20, 2010
Publication date	Jul 19, 2016
Grant date	Jul 19, 2016

Abstract

Measurement systems and methods are disclosed for minimizing the effects created by a meter's output amplifier during electrochemical measurements. In the systems and methods, transition of an excitation potential applied between electrodes of a test strip is controlled so that it is at a sufficiently slow rate below a slew rate capability of the system (but still fast enough to minimally impact overall test time) to reduce variability in the test results. The methods and systems therefore use a transition having a ramp-shaped waveform, a sinusoidal-shaped waveform or an exponential-shaped waveform. Additionally, the excitation potential can be purposefully controlled by a processor, memory driven digital-to-analog converter or external circuitry at a rate sufficiently slow to make variations in the analog electronics slew rate insignificant for all sample types and test conditions.

First claim

The invention claimed is:

1. A method of electrochemical analysis, the method comprising the steps of:
providing an electrochemical test strip with a mediator system and electrodes;
introducing a body fluid sample to the mediator system and in contact with electrodes of the test strip;
applying an excitation potential difference between the electrodes of the test strip and across the body fluid sample, wherein the excitation potential difference has a transition time of at least 100 μsec, wherein the applying the excitation potential difference step is performed by a meter having a slew rate capability, wherein the slew rate at which the meter applies the excitation potential difference is slower than the slew rate capability of the meter, and wherein the excitation potential difference is at least 300 mV and the slew rate is at most about 900 V/sec; and
determining analyte concentration in the body fluid sample based on an electrical response to said excitation potential difference.

2. The method of claim 1 , wherein the application of the excitation potential difference has a shape selected from the group consisting of a ramp-shaped waveform, a sinusoidal-shaped waveform, and an exponential-shaped waveform.

3. The method of claim 1 , wherein the excitation potential difference is selected from the group consisting of at least about 300 mV, at least about 450 mV, and at least about 550 mV.

4. The method of claim 1 , wherein the meter includes a processor and/or memory driven digital-to-analog converter that controls the slew rate at a rate sufficiently slow to make variations in analog electronics properties insignificant.

5. The method of claim 1 , wherein the meter includes a voltage follower arrangement.

6. The method of claim 1 , wherein the meter performs said applying the excitation potential difference and said determining the analyte concentration; and the method further comprising: outputting the analyte concentration with the meter.

7. The method of claim 1 further comprising the steps of:
providing a second electrochemical test strip with the mediator system and electrodes being the same type as the first electrochemical test strip;
introducing a second body fluid sample to the mediator system and in contact with electrodes of the second test strip;
applying a second excitation potential difference between the electrodes of the second test strip and across the second body fluid sample with a second meter that has different electrical properties than the meter, wherein the second excitation potential difference has a transition time of at least 5 msec; and
determining analyte concentration in the second body fluid sample based on a second electrical response to said applying the second excitation potential difference.

8. The method of claim 1 , wherein the body fluid sample comprises blood and the analyte concentration includes glucose concentration.

9. The method of claim 1 , wherein the determining analyte concentration step includes using an amperometric analysis technique.

10. A method of reducing measurement error between different meter platforms, the method comprising the steps of:
analyzing glucose concentrations in blood with the same type of test strips on at least two different meter platforms that have different slew rate capabilities; and
performing on each of the different meter platforms an electrochemical analysis protocol in which each meter platform applies to electrodes of the test strips excitation potential differences with transition times of at least 5 msec.

11. The method of claim 10 , wherein application of the excitation potential differences has a shape selected from the group consisting of a ramp-shaped waveform, a sinusoidal-shaped waveform, and an exponential-shaped waveform.

12. The method of claim 10 , wherein the excitation potential differences are selected from the group consisting of at least about 300 mV, at least about 450 mV, and at least about 550 mV.

13. The method of claim 10 , further comprising the step of outputting the glucose concentrations with the meter platforms.

14. A biosensor measurement system comprising:
at least a potentiostat and measurement electronics, wherein the system has a slew rate capability dependent upon one or both of the potentiostat and measurement electronics, wherein the measurement electronics comprises a processor configured to control rate of application of an excitation potential by the potentiostat of an excitation potential between two electrical terminals and having a magnitude, wherein the rate of application of the excitation potential is at a rate slower than the slew rate capability of the system and the magnitude of the excitation potential is at least 300 mV and the slew rate is at most about 900 V/sec.

15. The system of claim 14 , wherein the rate of application of the excitation potential comprises a transition time between about 100 μsec and about 5 msec.

16. The system of claim 14 , wherein the rate of application of the excitation potential comprises a transition time of at least about 100 μsec to reach the magnitude of the excitation potential.

17. The system of claim 14 , wherein the processor is configured to control the potentiostat to apply the excitation potential in as shape selected from the group consisting of a ramp-shaped waveform, a sinusoidal-shaped waveform, and an exponential-shaped waveform.

18. The system of claim 14 , wherein the magnitude of the excitation potential is at least about 450 mV or at least about 550 mV.

19. The system of claim 14 , further comprising a biosensor having at least a pair of electrically isolated electrodes in electrical communication with respective ones of the two electrical terminals, wherein the biosensor further comprises an electrochemical cell defined generally by the pair of electrodes, the cell having a time constant determined at least in part by one of the resistance or capacitance of the electrodes and the resistance or capacitance of the cell having a fluid sample applied thereto, wherein the slew rate capability is at least equal to the time constant of the cell.

Assignees

• Roche Diabetes Care Inc

Inventors

• Beaty Terry A

Classifications

• G01N27/48 Primary

  using polarography, i.e. measuring changes in current under a slowly-varying voltage · CPC title

• G01N27/3273 Primary

  Devices therefor, e.g. test element readers, circuitry (details not specific to biochemical electrodes G01N33/4875) · CPC title