Methods and compositions for generating oligodendrocyte progenitor cells
US-2024158744-A1 · May 16, 2024 · US
Self-renewal promoter for neural stem cells and method for using same
US9394516B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9394516-B2 |
| Application number | US-201113643337-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 26, 2011 |
| Priority date | Apr 26, 2010 |
| Publication date | Jul 19, 2016 |
| Grant date | Jul 19, 2016 |
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Abstract
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An object of the present invention to provide an agent for promoting the self-renewal of the neural stem cells and a method of using the same. ECF-L contained in a culture supernatant of endothelial progenitor cells derived from bone marrow has an effect of promoting the self-renewal of neural stem cells. Accordingly, ECF-L can be used as an ingredient of an agent for promoting the self-renewal of the neural stem cells, a pharmaceutical composition for growing the neural stem cells, and a pharmaceutical composition for treating a disease associated with neural dysfunction.
First claim
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The invention claimed is: 1. A method of culturing neural stem cells, comprising: culturing the neural stem cells in a medium comprising an effective amount of a chitinase 3-like 3 protein to promote self-renewal of the neural stem cells in culture, wherein the chitinase 3-like 3 protein is a recombinant protein. 2. The method according to claim 1 , wherein the chitinase 3-like 3 protein is Ym1.
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Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for disorders of the cardiovascular system · CPC title
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title
for treating abnormal movements, e.g. chorea, dyskinesia · CPC title
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title
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- What does patent US9394516B2 cover?
- An object of the present invention to provide an agent for promoting the self-renewal of the neural stem cells and a method of using the same. ECF-L contained in a culture supernatant of endothelial progenitor cells derived from bone marrow has an effect of promoting the self-renewal of neural stem cells. Accordingly, ECF-L can be used as an ingredient of an agent for promoting the self-renewal…
- Who is the assignee on this patent?
- Namiki Jun, Okano Hideyuki, Univ Keio
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0623. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 19 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).