Device for determining illumination distributions for IMRT

Patent metadata

Field	Value
Publication number	US-9393442-B2
Application number	US-201414891074-A
Country	US
Kind code	B2
Filing date	May 14, 2014
Priority date	May 29, 2013
Publication date	Jul 19, 2016
Grant date	Jul 19, 2016

Abstract

The invention relates to a device for determining illumination distributions ( 18 ) for IMRT. A layered graph structure is used, which considers which extensions of an illumination distribution along a respective line and thus which illumination distributions are realizable, for determining extensions for the illumination distributions. Moreover, second weights defining fluences of the illumination distributions are determined such that a deviation between a provided fluence map and a fluence map formed by a combination of illumination distributions, which are defined by the respective determined extensions and the respective second weight, is minimized. This determination procedure leads to illumination distributions, which very well correspond to the provided fluence map and which are automatically realizable by the radiation device. This leads to an improved IMRT, wherein a post-processing of the determined illumination distributions for ensuring that the determined illumination distributions are really realizable is not necessarily required.

First claim

The invention claimed is:

1. A device for determining illumination distributions to be directed to a target region for performing intensity modulated radiation therapy, the device comprising:
a fluence map providing unit for providing a fluence map,
a layered graph structure providing unit for providing a layered graph structure, wherein the layered graph structure comprises layers with nodes, wherein the nodes of a layer represent realizable extensions of an illumination distribution along a line, which are realizable by a radiation device, wherein the nodes of different layers represent realizable extensions of an illumination distribution along different parallel lines and wherein nodes of adjacent layers are connected by graph edges, to which first weights and regularization values are assigned, wherein the regularization values depend on deviations between the extensions of the illumination distributions represented by the nodes connected by the respective graph edges,
an extensions determination unit for determining extensions of an illumination distribution along the parallel lines for several illumination distributions, wherein the extensions determination unit is adapted to determine the extensions for an illumination distribution by determining a sequence of nodes connected by the graph edges through the layered graph structure, which optimizes a cost function that depends on a combination of the first weights and the regularization values assigned to the graph edges connecting the nodes of the sequence, thereby determining a contour of the illumination distribution,
a second weights determination unit for determining second weights defining the fluences of the illumination distributions, for which the extensions have been determined, such that a deviation between the provided fluence map and a combination of the illumination distributions having the determined extensions and the fluences defined by the second weights is minimized.

2. The device as defined in claim 1 , wherein the radiation device comprises a combination of a radiation source and a multileaf collimator, wherein the lines, along which the extensions of the illumination distributions are defined, are aligned along the leafs of the multileaf collimator and wherein realizable positions of the leafs of the multileaf collimator define the realizable extensions of the illumination distribution along the respective line.

3. The device as defined in claim 1 , wherein the layered graph structure providing unit is adapted to determine a deviation function being indicative of a deviation between the provided fluence map and the combination of illumination distributions having the determined extensions and the fluences defined by the second weights and to determine the first weights depending on the deviation function.

4. The device as defined in claim 3 , wherein the layered graph structure providing unit is adapted to determine the first weights depending on gradients of the deviation function.

5. The device as defined in claim 4 , wherein the layered graph structure providing unit is adapted to determine a first weight for a graph edge depending on the gradients for the extensions represented by the nodes connected by the graph edge.

6. The device as defined in claim 3 , wherein the deviation function is indicative of the sum of squared differences between the provided fluence map and the combination of illumination distributions having the determined extensions and the fluences defined by the second weights.

7. The device as defined in claim 1 , wherein the layered graph structure providing unit is adapted to assign an infinite value as a first weight to a graph edge for indicating an impossible transfer from one of the nodes connected by the graph edge to another of the nodes connected by the graph edge, if the combination of extensions of the illumination distribution represented by these nodes is not realizable by the radiation device.

8. The device as defined in claim 1 , wherein the layered graph structure providing unit and the extensions determination unit are adapted such that, after the extensions determination unit has determined extensions of an illumination distribution:
nodes of the layered graph structure are selected based on a selection criterion which depends on the determined extensions,
regularization values are assigned to the graph edges, and
the extensions of the illumination distribution are determined again, wherein only the selected nodes are considered.

9. The device as defined in claim 1 , wherein the layered graph structure providing unit, the extensions determination unit and the second weights determination unit are adapted such that the provision of the layered graph structure, the determination of the extensions and the determination of the second weights is repeatedly performed.

10. The device as defined in claim 9 , wherein the layered graph structure providing unit is adapted to repeatedly provide the layered graph structure by repeatedly determining the first weights.

11. An apparatus for performing intensity modulated radiation therapy, the apparatus comprising:
a radiation device for providing illumination distributions to be directed to a target region,
a device for determining illumination distributions realizable by the radiation device and to be directed to the target region for performing intensity modulated radiation therapy as defined in claim 1 , and
a control unit for controlling the radiation device in accordance with the determined illumination distributions.

12. A method for determining illumination distributions to be directed to a target region for performing intensity modulated radiation therapy, the method comprising:
providing a fluence map by a fluence map providing unit,
providing a layered graph structure by a layered graph structure providing unit, wherein the layered graph structure comprises layers with nodes, wherein the nodes of a layer represent realizable extensions of an illumination distribution along a line, which are realizable by a radiation device, wherein the nodes of different layers represent realizable extensions of an illumination distribution along different parallel lines and wherein nodes of adjacent layers are connected by graph edges, to which first weights and regularization values are assigned, wherein the regularization values depend on deviations between the extensions of the illumination distributions represented by the nodes connected by the respective graph edges,
determining extensions of an illumination distribution along the parallel lines for several illumination distributions by an extensions determination unit, wherein the extensions are determined for an illumination distribution by determining a sequence of nodes connected by the graph edges through the layered graph structure, which optimizes a cost function that depends on a combination of the first weights and the regularization values assigned to the graph edges connecting the nodes of the sequence, thereby determining a contour of the illumination distribution,
determining second weights defining the fluences of the illumination distributions, for which the extensions have been determined, by a second weights determination unit such that a deviation between the provided fluence map and a combination of the illumination distributions having the determined extensions and the fluences defined by the second weights is minimized.

13. A computer program for determining illumination distributions to be directed to a target region for performing intensity modulated radiation therapy, the computer program comprising non-transitory program code means

Assignees

• Koninkl Philips Nv

Inventors

• Isola Alfonso Agatino
• Neukirchen Christoph
• Weese Juergen
• Bal Matthieu Frédéric

Classifications

• A61N2005/1074

  Details of the control system, e.g. user interfaces · CPC title

• A61N5/1045

  using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT · CPC title

• A61N5/1047

  with movement of the radiation head during application of radiation, e.g. for intensity modulated arc therapy or IMAT · CPC title

• A61N5/1036 Primary

  Leaf sequencing algorithms · CPC title