Multi-lumen biologic-delivering device

Patent metadata

Field	Value
Publication number	US-9393364-B2
Application number	US-201313943314-A
Country	US
Kind code	B2
Filing date	Jul 16, 2013
Priority date	Jul 17, 2012
Publication date	Jul 19, 2016
Grant date	Jul 19, 2016

Abstract

Arrangements and methods for delivering bioactive agents and/or cells into an extended volume of tissue are disclosed. In one embodiment, a cell-delivering needle arrangement has a tube positioned within a tube and fixedly attached to a wall thereof. In one exemplary method, a cell-delivering needle is advanced into tissue, a suspension of cells is passed through a first lumen and out of side ports, and a suspension of cells is passed through a second lumen and out of a distal opening. Other embodiments are disclosed.

First claim

What is claimed is:

1. A method of delivering a biologic material into an extended volume of tissue of a patient, comprising:
advancing a distal end region of a biologic-material-delivering needle having an elongated body defining a first lumen, a second lumen, a plurality of side ports associated with said first lumen, an end port associated with said second lumen, and a tissue-penetrating tip through the skin of the patient;
passing a first suspension of biologic material through said first lumen and out of said plurality of side ports associated with said first lumen to release a biologic material from said plurality of side ports towards tissue adjacent to said elongated body; and
passing a second suspension of biologic material through said second lumen and out of said end port without passing said second suspension through any of said plurality of side ports, to release a biologic material from said end port into tissue of the patient;
wherein passing a first suspension of biologic material through said first lumen and out of said plurality of side ports associated with said first lumen occurs at a higher pressure than said passing a second suspension of biologic material through said second lumen and out of said end port associated with said second lumen.

2. The method of claim 1 , wherein:
said biologic material comprises cells.

3. The method of claim 1 , wherein:
said second lumen is defined by a second elongate body positioned within said first lumen and said second elongate body is surrounded by an annular space.

4. The method of claim 1 , wherein:
said second lumen is defined by a second elongate body positioned within said first lumen and fixedly coupled to a wall thereof.

5. The method of claim 1 , further comprising:
withdrawing said biologic-material-delivering needle while passing said first or second suspension of biologic material into a biologic-material-delivering needle tract.

6. The method of claim 1 , wherein:
said plurality of side ports are positioned around the periphery of the elongated body.

7. The method of claim 5 , wherein:
passing said first or second suspension of biologic material into the biologic material-delivery needle tract comprises passing said second suspension of biologic material through said second lumen and out of said end port associated with said second lumen.

8. The method of claim 7 , further comprising:
passing said first suspension of biologic material through said first lumen and out of said plurality of side ports associated with said first lumen while withdrawing said biologic-material-delivering needle.

9. The method claim 1 , further comprising:
connecting a first injecting member to a first connecting member of said biologic-material-delivering needle for fluid communication with said first lumen.

10. The method of claim 9 , further comprising:
connecting a second injecting member to a second connector of said biologic-material-delivering needle for fluid communication with said second lumen.

11. The method of claim 1 , wherein:
said second suspension of biologic material passing through said second lumen and out of said distal opening has a greater pressure loss than said first suspension of biologic material passing through said first lumen and out of said ports.

12. The method of claim 1 , wherein:
said first lumen and said second lumen are fixedly positioned to one another.

13. The method of claim 1 , wherein:
each of said plurality of side ports has a cross-sectional area measured perpendicular to a longitudinal axis of the side port;
wherein said end port has a cross-sectional area measured perpendicular to a longitudinal axis of said end port; and
wherein said cross-sectional area of each of said plurality of side ports is smaller than the cross-sectional area of said end port.

14. The method of claim 1 , wherein:
said second lumen has a cross-sectional area measured perpendicular to a longitudinal axis of said second lumen;
wherein said first lumen has a cross-sectional area measured perpendicular to a longitudinal axis of said first lumen; and
wherein said cross-sectional area of said second lumen is smaller than said cross-sectional area of said first lumen.

15. The method claim 1 , wherein:
said second lumen is positioned within said first lumen.

16. The method of claim 15 , wherein:
said second lumen is surrounded by an annular space.

17. The method of claim 1 , wherein:
a distal end of said second lumen extends beyond a distal end of said first lumen.

18. The method of claim 1 , wherein:
the biologic-material-delivering needle has a plug closing a distal end of said first lumen.

19. The method of claim 1 , wherein:
the biologic-material-delivering needle has a proximal end region, a distal end region, a first elongated body, and a second elongated body;
said first elongated body having a sidewall defining the first lumen extending from said proximal end region to said distal end region;
said first lumen terminating in a closed distal end and communicating with the plurality of side ports defined by said sidewall and positioned around the periphery of said first elongated body;
said second elongated body positioned within said first lumen and fixedly coupled to a wall thereof;
said second elongated body defining the second lumen extending from said proximal end region to said distal end region and communicating with the end port in said distal end region; and
said distal end region of said needle body having a tissue-penetrating needle tip.

20. The method of claim 1 , wherein:
said first suspension of biologic material exiting said plurality of side ports associated with said first lumen occurs at a higher velocity than said second suspension of biologic material exiting said end port associated with said second lumen.

21. A method of delivering a biologic material into an extended volume of tissue of a patient, comprising:
advancing a distal end region of a biologic-material-delivering needle having an elongated body having a first surface defining a first lumen, a second surface defining a second lumen, a plurality of side ports associated with said first lumen, an end port associated with said second lumen, and a tissue-penetrating tip through the skin of the patient;
passing a first suspension of biologic material through said first lumen in contact with said first surface and out of said plurality of side ports associated with said first lumen to release a biologic material from said plurality of side ports towards tissue adjacent to said elongated body; and
passing a second suspension of biologic material through said second lumen in contact with said second surface and out of said end port associated with said second lumen to release a biologic material from said end port into tissue of the patient;
wherein said first suspension of biologic material exiting said plurality of side ports has a higher pressure than said second suspension of biologic material exiting said end port.

22. The method of claim 21 , wherein:
said first suspension of biologic material exiting said plurality of side ports associated with said first lumen occurs at a higher velocity than said second suspension of biologic material exiting said end port associated with said second lumen.

Assignees

• Cook Medical Technologies Llc

Inventors

• Fischer Jr Frank J

Classifications

• A61M5/3298

  Needles arranged in parallel · CPC title

• A61M5/329

  characterised by features of the needle shaft · CPC title

• A61M25/007 Primary

  Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked · CPC title

• A61M2202/097

  endothelial cells · CPC title

• A61M5/3295

  Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel · CPC title