Absorbable coating for implantable device

Patent metadata

Field	Value
Publication number	US-9387282-B2
Application number	US-201414182211-A
Country	US
Kind code	B2
Filing date	Feb 17, 2014
Priority date	Mar 31, 2010
Publication date	Jul 12, 2016
Grant date	Jul 12, 2016

Abstract

The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.

First claim

The invention claimed is:

1. A medical device, comprising:
(a) a bio-absorbable stent; and
(b) a bio-absorbable coating layer disposed over the bio-absorbable stent, the bio-absorbable coating layer comprises a reservoir layer consisting of D,L-PLA and novolimus, wherein
(i) the D,L-PLA has a number average molecular weight below 60,000 Daltons, and
(ii) the coating layer has a thickness of less than 5 microns.

2. A medical device, comprising:
(a) a bio-absorbable stent; and
(b) a bio-absorbable coating, the bio-absorbable coating comprises a reservoir layer comprising D,L-PLA and novolimus, wherein
(i) the D,L-PLA has a number average molecular weight below 60,000 Daltons, and
(ii) the coating has a thickness of less than 5 microns.

3. A medical device, comprising:
(a) a bio-absorbable stent; and
(b) a coating layer, the coating layer comprising a reservoir layer consisting essentially of D,L-PLA and novolimus, wherein
(i) the D,L-PLA has a number average molecular weight below 60,000 Daltons, and
(ii) the coating layer has a thickness of less than 5 microns.

4. The device of claim 3 , wherein the coating layer additionally consists of BHT.

5. The device of claim 2 , wherein the coating layer additionally comprises lactide monomers and/or oligomers.

6. The device of claim 3 , wherein the coating layer additionally consists of lactide monomers and/or oligomers.

7. The device of claim 3 , wherein the coating layer additionally consists of —COOH terminated oligomers of D, L-PLA.

8. The medical device of claim 1 , wherein the bio-absorbable coating layer additionally comprises a primer layer.

9. The medical device of claim 2 , wherein the bio-absorbable coating additionally comprises a primer layer.

10. The medical device of claim 3 , wherein the coating layer additionally comprises a primer layer.

11. The medical device of claim 1 , wherein the bio-absorbable coating layer completely or substantially completely absorbs upon implantation in a human body within a period from about 3 months to about 6 months.

12. The medical device of claim 2 , wherein the bio-absorbable coating completely or substantially completely absorbs upon implantation in a human body within a period from about 3 months to about 6 months.

13. The medical device of claim 3 , wherein the coating layer completely or substantially completely absorbs upon implantation in a human body within a period from about 3 months to about 6 months.

14. An implantable medical device, comprising:
(a) a bio-absorbable stent; and
(b) a reservoir layer disposed over the stent to form a coating, the reservoir layer comprising D,L-PLA and novolimus, wherein
(i) the D,L-PLA has a number average molecular weight below 60,000 Daltons, and
(ii) the coating has a thickness of less than 5 microns.

Assignees

• Abbott Cardiovascular Systems

Inventors

• Kleiner Lothar W
• Hossainy Syed F A
• Trollsas Mikael
• Pacetti Stephen D

Classifications

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title

• A61P7/04

  Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title