Use of SDF-1 to improve ischemic myocardial function

Patent metadata

Field	Value
Publication number	US-9387234-B2
Application number	US-201313938608-A
Country	US
Kind code	B2
Filing date	Jul 10, 2013
Priority date	Jun 5, 2000
Publication date	Jul 12, 2016
Grant date	Jul 12, 2016

Abstract

A method is provided for increasing trafficking of endothelial progenitor cells to an ischemic myocardium in a subject's heart comprising administering to the subject's heart an amount of Stromal-Derived Factor-1 (SDF-1).

First claim

What is claimed:

1. A method comprising administering Stromal-Derived Factor-1 (SDF-1) to ischemia damaged tissue of a subject to thereby treat the ischemia damaged tissue by stimulating angiogenesis and/or vasculogenesis, wherein the ischemia damaged tissue is myocardium.

2. The method of claim 1 , wherein the SDF-1 is administered in an amount effective to attract endothelial progenitor cells to the ischemia damaged tissue.

3. The method of claim 1 , wherein the SDF-1 is administered by injection into the ischemia damaged tissue.

4. The method of claim 3 , wherein the endothelial progenitor cells are bone marrow-derived endothelial progenitor cells.

5. The method according to claim 1 additionally comprising administering endothelial progenitor cells to the subject.

6. The method of claim 1 , wherein the subject has suffered or is suffering from one or more of the following: myocardial infarction, chronic heart failure, ischemic heart disease, coronary artery disease, diabetic heart disease, hemorrhagic stroke, thrombotic stroke, embolic stroke, and limb ischemia.

7. The method of claim 1 , wherein the SDE-1 is administered in an amount effective to improve cardiac function in the subject.

8. The method of claim 1 , further comprising administering to the subject one or more of the following: an inhibitor of Plasminogen Activator Inhibitor, Angiotensin Converting Enzyme Inhibitor or a beta blocker.

Assignees

• Itescu Silviu
• Univ Columbia

Inventors

• Itescu Silviu

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/08

  Vasodilators for multiple indications · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title

• A61P35/00

  Antineoplastic agents · CPC title