Phosphonate Compounds
US-2015051174-A1 · Feb 19, 2015 · US
US9387217B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9387217-B2 |
| Application number | US-201514874027-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 2, 2015 |
| Priority date | Mar 15, 2013 |
| Publication date | Jul 12, 2016 |
| Grant date | Jul 12, 2016 |
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The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
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What is claimed is: 1. A method for treating an HPV viral infection in a host in need thereof comprising administering an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier. 2. The method of claim 1 , wherein the viral infection is HPV 11. 3. The method of claim 1 , wherein the viral infection is HPV 16. 4. The method of claim 1 , wherein the viral infection is HPV 18. 5. The method of claim 1 , wherein the host is a human. 6. The method of claim 2 , wherein the host is a human. 7. The method of claim 3 , wherein the host is a human. 8. The method of claim 4 , wherein the host is a human. 9. The method of claim 5 , wherein the pharmaceutically acceptable carrier is suitable for topical delivery. 10. The method of claim 6 , wherein the pharmaceutically acceptable carrier is suitable for topical delivery. 11. The method of claim 7 , wherein the pharmaceutically acceptable carrier is suitable for topical delivery. 12. The method of claim 8 , wherein the pharmaceutically acceptable carrier is suitable for topical delivery.
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