Device and method for enhanced subcutaneous insulin absorption

Patent metadata

Field	Value
Publication number	US-9387033-B2
Application number	US-200913060799-A
Country	US
Kind code	B2
Filing date	Aug 27, 2009
Priority date	Aug 28, 2008
Publication date	Jul 12, 2016
Grant date	Jul 12, 2016

Abstract

Products and methods directed to the improved infusion of fluids are disclosed. Such products and methods can be used to more efficiently and efficaciously administer therapeutic pharmaceuticals to a subject in need of treatment. In many instances, the systems comprise a therapeutic fluid delivery system and a mechanism for enhancing the absorption of the therapeutic fluid. The enhancement of the absorption of the therapeutic fluid is generally performed locally i.e., at or near the site of administration of the therapeutic fluid. The system and methods can be used to deliver any number of therapeutic fluids including but not limited to insulin.

First claim

What is claimed is:

1. A system for delivering a therapeutic fluid to a body of a patient comprising:
a pump including:
a reservoir for retaining the therapeutic fluid,
a driving mechanism which dispenses via pumping the therapeutic fluid from the reservoir to the body of the patient,
electronic components which control, at least in part, operation of the driving mechanism, and
a power supply which powers at least the driving mechanism and the electronic components;

a first subcutaneously insertable element for delivering the therapeutic fluid therethrough to the body of the patient, the first subcutaneously insertable element comprises a distal portion configured for subcutaneous placement within the body of the patient; and
an absorption enhancement device configured to contact and locally heat tissue of the patient surrounding the first subcutaneously insertable element when subcutaneously placed, which causes an increase in absorption rate of the therapeutic fluid in the body of the patient, wherein the electronic components control the operation of the absorption enhancement device, and wherein the electronic components are contained in a reusable part, and that the reservoir is contained in a disposable part, the disposable part also provides the first subcutaneously insertable element and the absorption enhancement device, and wherein the system further comprises a skin adherable cradle unit having an elastically deformable anchoring latch at each opposing end, such that one opposing end of the skin adherable cradle unit extends upward directly against and along an opposing exterior side of the reusable part, and an other opposing end of the skin adherable cradle unit extends upwardly directly against and along an opposing exterior side of the disposable part,
the anchoring latches hold both the reusable part and the disposable part horizontally side-by-side via a snapping engagement of a top portion of the anchoring latches with a pair of lateral notches, where one lateral notch is provided on the opposing exterior sides of the reusable part and an other lateral notch is provided on the opposing exterior side of the disposable part,
and wherein the first subcutaneously insertable element and the absorption enchancement device. extend downwardly in an opening provided in the skin adherable cradle unit such that the distal portion can be placed subcutaneously within the body of the patient, and the absorption enhancement device can contact and locally heat surrounding tissue of the patient when the first subcutaneously insertable element is subcutaneously placed.

2. The system of claim 1 , wherein the absorption enhancement device comprises one or more heating plates disposed on the disposable part.

3. The system of claim 2 , wherein the first subcutaneously insertable element is a cannula, the disposable part includes an outlet port from which the cannula extends, and wherein the one or more heating plates are arranged concentrically around the outlet port.

4. The system of claim 2 , wherein the first subcutaneously insertable element is a cannula, the disposable part includes an outlet port from which the cannula extends, and wherein the one or more heating plates is a rounded heating plate arranged concentrically around the outlet port.

5. The system of claim 1 , wherein the first subcutaneously insertable element is a cannula, and wherein the absorption enhancement device comprises at least one electrode associated with the cannula.

6. The system of claims 1 , wherein the absorption enhancement device is electrically connected to the power supply.

7. The system of claim 1 , wherein the absorption enhancement device is activated in accordance with a planned meal.

8. The system of claim 1 , wherein the therapeutic fluid comprises insulin.

9. The system of claim 1 , wherein the electronic components control the operation of the absorption enhancement device, wherein the first subcutaneously insertable element is a cannula, wherein the disposable part includes an outlet port from which the cannula extends, the absorption enhancement device comprises one or more heating plates disposed on the disposable part and arranged concentrically around the outlet port, and wherein the absorption enhancement device is electrically connected to the power supply.

10. The system of claim 1 , wherein the power supply is provided in the disposable part.

11. The system of claim 1 , wherein the power supply is provided in the reusable part.

Assignees

• Yodfat Ofer
• Shapira Gali
• Gescheit Illai
• Roche Diabetes Care Inc

Inventors

• Yodfat Ofer
• Shapira Gali
• Gescheit Illai

Classifications

• A61M2205/36

  related to heating or cooling · CPC title

• A61B2017/00765

  Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation · CPC title

• A61B18/14 Primary

  Probes or electrodes therefor · CPC title

• A61M2230/201

  Glucose concentration · CPC title

• A61B18/20

  using laser · CPC title