Compositions and methods for treating obesity and related disorders by characterizing and restoring mammalian bacterial microbiota

Patent metadata

Field	Value
Publication number	US-9386793-B2
Application number	US-201113214034-A
Country	US
Kind code	B2
Filing date	Aug 19, 2011
Priority date	Aug 20, 2010
Publication date	Jul 12, 2016
Grant date	Jul 12, 2016

Abstract

The present invention relates to characterizing changes in mammalian intestinal microbiota associated with associated with high-fat and low-fat diets and with diets containing hydroxypropylmethylcellulose (HPMC) and related methods for diagnosing, preventing and treating obesity and related conditions such as metabolic syndrome and diabetes mellitus. Therapeutic methods of the invention involve the use of probiotics, and/or prebiotics, and/or narrow spectrum antibiotics/anti-bacterial agents that are capable of restoring healthy mammalian bacterial intestinal microbiota.

First claim

What is claimed:

1. A method for preventing weight gain in a mammal in need thereof comprising administering to the mammal a therapeutically effective amount of a probiotic composition comprising at least one strain from the genus Dorea.

2. The method of claim 1 , wherein said strain is selected from the group consisting of live bacterial strains, spores and conditionally lethal bacterial strains.

3. The method of claim 1 , wherein the probiotic composition is administered conjointly with a prebiotic composition which stimulates growth and/or metabolic activity of bacteria contained in the probiotic composition.

4. The method of claim 3 , wherein the probiotic and prebiotic compositions are administered in one composition, or simultaneously as two separate compositions, or sequentially.

5. The method of claim 1 , wherein the probiotic composition is administered orally or rectally.

6. The method of claim 1 , wherein the probiotic composition is administered in a form of a capsule or in a form of a suppository.

7. The method of claim 1 , wherein the mammal is human.

Assignees

• Blaser Martin J
• Cox Laura
• Cho Ilseung
• Univ New York

Inventors

• Blaser Martin J
• Cox Laura
• Cho Ilseung

Classifications

• A61P3/08

  for glucose homeostasis (pancreatic hormones A61P5/48) · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A61K35/741 Primary

  Probiotics (probiotic yeast, e.g. saccharomyces A61K36/06) · CPC title