Antimicrobial elastomeric articles

Patent metadata

Field	Value
Publication number	US-9386772-B2
Application number	US-201213396260-A
Country	US
Kind code	B2
Filing date	Feb 14, 2012
Priority date	Feb 14, 2012
Publication date	Jul 12, 2016
Grant date	Jul 12, 2016

Abstract

The present invention relates generally to methods of preparing antimicrobial elastomeric articles that include an elastomeric article having an antimicrobial coating provided thereon. The antimicrobial elastomeric articles exhibit enhanced ability to reduce or eliminate microbes that come in contact with the article. Certain aspects of the invention are further directed to methods of packaging the antimicrobial elastomeric articles, where the packaged antimicrobial articles exhibit antimicrobial effectiveness for an extended period of time as compared to unpackaged antimicrobial articles. Antimicrobial elastomeric articles and packaged antimicrobial elastomeric articles prepared in accordance with the methods of the present invention are also provided.

First claim

What is claimed:

1. A method for preparing an antimicrobial elastomeric article, comprising:
exposing an elastomeric article to an environment comprising about 10.3 g/m 3 or less absolute humidity;
coating the elastomeric article with an antimicrobial coating composition to form an antimicrobial elastomeric article;
exposing the antimicrobial elastomeric article to an environment comprising about 10.3 g/m 3 or less absolute humidity; and
packaging the antimicrobial elastomeric article in a packaging system that does not comprise a desiccant selected from the group consisting of silica gel, aerogel, bentonite clay, activated alumina, nitrogen gas, and argon gas;
wherein the antimicrobial elastomeric article, when aged in the packaging system for 7 days at 70°C., has an antimicrobial efficacy such that the number of microorganisms present on a surface of the antimicrobial elastomeric article is reduced by at least 4 log 10 within 5 minutes.

2. The method of claim 1 , wherein the elastomeric article is exposed to the environment for a period of from about 12 to about 48 hours.

3. The method of claim 1 , wherein the antimicrobial elastomeric article is exposed to the environment for a period of from about 12 to about 48 hours.

4. The method of claim 1 , wherein the environment comprising about 10.3 g/m 3 or less absolute humidity is maintained by a structure selected from the group consisting of rooms, bags, packages, boxes, and totes.

5. The method of claim 4 , wherein the structure further comprises a desiccant selected from the group consisting of silica gel, aerogel, bentonite clay, activated alumina, nitrogen gas, and argon gas.

6. The method of claim 1 , wherein the antimicrobial coating composition comprises an antimicrobial agent, a hydrophilic polymer, and a hydrophobic oligomer.

7. The method of claim 6 , wherein the antimicrobial agent is selected from the group consisting of biguanides, rifampin, minocycline, silver compounds, triclosan, quaternary ammonium compounds, iron-sequestering glycoproteins, cationic polypeptides, surfactants, zinc pyrithione, broad-spectrum antibiotics, antiseptic agents, and combinations thereof.

8. The method of claim 7 , wherein the antimicrobial agent comprises chlorhexidine gluconate.

9. The method of claim 7 , wherein the biguanides are selected from the group consisting of chlorhexidine digluconate (CHG), chlorhexidine diacetate, chlorhexidine dihydrochloride, chlorhexidine diphosphanilate, and poly(hexamethylene biguanide) (PHMB).

10. The method of claim 7 , wherein the silver compounds are selected from the group consisting of silver chloride, silver oxide, and silver sulfadiazine.

11. The method of claim 7 , wherein the quaternary ammonium compounds are selected from the group consisting of benzalkonium chloride, tridodecyl methyl ammonium chloride, didecyl dimethyl ammonium chloride, chloroallyl hexaminium chloride, benzethonium chloride, methylbenzethonium chloride, cetyl trimethyl ammonium bromide, cetyl pyridinium chloride, and dioctyldimethyl ammonium chloride.

12. The method of claim 7 , wherein the iron-sequestering glycoproteins are selected from the group consisting of lactoferrin and ovotransferrin/conalbumin.

13. The method of claim 7 , wherein the cationic polypeptides are selected from the group consisting of protamine, polylysine, and lysozyme.

14. The method of claim 7 , wherein the surfactants are selected from the group consisting of SDS, Tween-80, surfactin, and Nonoxynol-9.

15. The method of claim 7 , wherein the broad-spectrum antibiotics are selected from the group consisting of quinolones, fluoroquinolones, aminoglycosides and sulfonamides.

16. The method of claim 7 , wherein the antiseptic agents are selected from the group consisting of iodine, methenamine, nitrofurantoin, and validixic acid.

17. The method of claim 6 , wherein the hydrophilic polymer comprises cationic acrylic copolymer of acrylic acid and methacrylic ester with quaternary ammonium groups.

18. The method of claim 6 , wherein the hydrophobic oligomer comprises a nonionic paraffin wax of 25-30 carbons in chain length.

19. The method of claim 1 , wherein the antimicrobial coating composition is applied by a technique selected from the group consisting of dipping, spraying, and tumbling.

20. The method of claim 19 , wherein the antimicrobial coating composition is applied while the elastomeric article is heated to about 55° C.

21. The method of claim 1 , further comprising a step of drying the antimicrobial elastomeric article at 55°C. ±5°C. for about 30 minutes after coating the elastomeric article with the antimicrobial coating composition.

22. The method of claim 1 , wherein the antimicrobial elastomeric article reduces the number of one or more microbes selected from the group consisting of coagulase-negative Staphylococci, Enterococci , fungi, Candida albicans, Staphylococcus aureus, Enterobacter species, Enterococcus faecalis, Staphylococcus epidermidis, Streptococcus viridans, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii, Burkholderia cepacia , Varicella, Clostridium difficile, Clostridium sordellii , Hepatitis A, Hepatitis B, Hepatitis C, HIV/AIDS, methicillin-resistant Staphylococcus aureus (MRSA), mumps, norovirus, parvovirus, poliovirus, rubella, SARS, S. pneumoniae , vancomycin-intermediate Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), and vancomycin-resistant Enterococci (VRE).

23. The method of claim 22 , wherein the S. pneumoniae is a drug-resistant form of S. pneuominae.

24. The method of claim 1 , wherein the packaging system comprises a packaging material selected from the group consisting of aluminum foil, polyethylene film, nylon film, and laminates thereof.

25. The method of claim 1 , wherein the relative humidity inside the packaging system is below about 50% relative humidity.

26. The method of claim 1 , wherein the antimicrobial elastomeric article has an antimicrobial efficacy such that the number of microorganisms present on a surface of the antimicrobial elastomeric article is reduced by at least 4 log 10 within 5 minutes for from about 8 to about 26 weeks following packaging.

27. The method of claim 26 , wherein the antimicrobial elastomeric article has an antimicrobial efficacy such that the number of microorganisms present on a surface of the antimicrobial elastomeric article is reduced by at least 4 log 10 within 5 minutes for at least 4 weeks following opening the packaging system to ambient atmospheric conditions.

28. The method of claim 1 , wherein the elastomeric article is selected from the group consisting of gloves, condoms, probe covers, and catheters.

29. A method for preparing an antimicrobial elastomeric article, comprising:
exposing an elastomeric article to an environment comprising about 10.3 g/m 3 or less absolute humidity;
coating the elastomeric article with an antimicrobial coating composition to form an antimicrobial elastomeric article; and
packaging the antimicrobial elastomeric article in a packaging system that does not comprise a desiccant selected from the group consisting of silica gel, aerogel, bentonite clay, activated alumina, nitrogen gas, and argon gas;
wherein the antimicrobial elastomeric article, when aged in the packaging sy

Assignees

• Krogman Nicholas
• Isaac Walt
• Wang Shipping
• Petrov Katia
• Allegiance Corp

Inventors

• Krogman Nicholas
• Isaac Walt
• Wang Shiping
• Petrov Katia

Classifications

• C08J2309/02

  Copolymers with acrylonitrile · CPC title

• A01N47/44 Primary

  Guanidine; Derivatives thereof · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61L31/10

  Macromolecular materials · CPC title

• C08J2433/08

  Homopolymers or copolymers of acrylic acid esters · CPC title