Neuraminidase inhibitor compounds, compositions and methods for the use thereof in anti-viral treatments

Patent metadata

Field	Value
Publication number	US-9382284-B2
Application number	US-201414533903-A
Country	US
Kind code	B2
Filing date	Nov 5, 2014
Priority date	Jul 15, 2009
Publication date	Jul 5, 2016
Grant date	Jul 5, 2016

Abstract

Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

First claim

What is claimed is:

1. A method of modulating viral neuraminidase activity comprising contacting a viral neuraminidase with a compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. The method according to claim 1 , wherein the viral neuraminidase is a GH34 neuraminidase.

3. The method according to claim 1 , wherein the viral neuraminidase is an influenza neuraminidase.

4. The method according to claim 3 , wherein modulating a viral neuraminidase comprises administering the compound or pharmaceutically acceptable salt thereof to an animal having influenza, and is effective to treat influenza in the animal.

5. The method according to claim 4 , wherein the animal is a mammal.

6. The method according to claim 4 , wherein the animal is a human.

7. A method of treating influenza in an animal comprising administering to the animal a compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof, wherein the compound modulates viral neuraminidase activity.

8. The method according to claim 7 , wherein the viral neuraminidase is a GH34 neuraminidase.

9. The method according to claim 7 , wherein the viral neuraminidase is an influenza neuraminidase.

10. The method according to claim 7 , wherein the animal is a mammal.

11. The method according to claim 7 , wherein the animal is a human.

12. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or excipient and a compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

Assignees

• Univ British Columbia

Inventors

• Withers Stephen
• Watts Andrew Graham
• Kim Jin Hyo
• Wennekes Tom

Classifications

• A61P31/16

  for influenza or rhinoviruses · CPC title

• C07H13/04

  having the esterifying carboxyl radicals attached to acyclic carbon atoms · CPC title

• C07H1/00

  Processes for the preparation of sugar derivatives · CPC title

• C07D309/14 Primary

  Nitrogen atoms not forming part of a nitro radical · CPC title

• A61K31/655

  Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds · CPC title