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Forms of vilazodone and processes for the preparation thereof
US9382233B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9382233-B2 |
| Application number | US-201314408257-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 13, 2013 |
| Priority date | Jun 13, 2012 |
| Publication date | Jul 5, 2016 |
| Grant date | Jul 5, 2016 |
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Abstract
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Vilazodone hydrochloride benzyl alcohol solvates are provided as well as processes for the preparation thereof.
First claim
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What is claimed is: 1. A crystalline benzyl alcohol solvate of vilazodone hydrochloride characterized by a PXRD diffractogram comprising peaks, in terms of degrees 2-theta at approximately 9.5, 10.6, 13.5, 15.6, 22.3 and 26.1 or at approximately 10.5, 13.3, 15.8, 19.5, 21.2, and 24.7. 2. The crystalline benzyl alcohol solvate of vilazodone hydrochloride of claim 1 , wherein the crystalline benzyl alcohol solvate of vilazodone hydrochloride is characterized by a PXRD diffractogram comprising peaks, in terms of degrees 2-theta, at approximately 9.5, 10.6, 13.5, 15.6, 22.3, and 26.1, and wherein the molar ratio of vilazodone hydrochloride to benzyl alcohol is approximately 1:0.5. 3. The crystalline benzyl alcohol solvate of vilazodone hydrochloride of claim 1 , wherein the crystalline benzyl alcohol solvate of vilazodone hydrochloride is characterized by a PXRD diffractogram comprising peaks, in terms of degrees 2-theta, at approximately 10.5, 13.3, 15.8, 19.5, 21.2, and 24.7, and wherein the molar ratio of vilazodone hydrochloride to benzyl alcohol is approximately 1:1. 4. The vilazodone hydrochloride benzyl alcohol solvate of claim 2 , wherein the PXRD diffractogram further comprises peaks, in terms of degrees 2-theta, at approximately 5.3, 11.2, 14.6, 17.5, 19.1, 20.5, and 24.5. 5. The vilazodone hydrochloride benzyl alcohol solvate of claim 2 characterized by a PXRD diffractogram substantially similar to the PXRD diffractogram as depicted in FIG. 1 . 6. The vilazodone hydrochloride benzyl alcohol solvate of claim 2 characterized by a 1% KBr FTIR spectrum comprising peaks, in terms of cm −1 , at approximately 3228, 2216, 1676, 1607, 1579, 1472, 1443, and 1380. 7. The vilazodone hydrochloride benzyl alcohol solvate of claim 6 characterized by a FTIR spectrum substantially similar to the FTIR spectrum as depicted in FIG. 2 . 8. The vilazodone hydrochloride benzyl alcohol solvate of claim 3 , wherein the PXRD diffractogram further comprises peaks, in terms of degrees 2-theta, at approximately 9.2, 18.6, 20.2, 22.3, 23.3, and 25.4. 9. The vilazodone hydrochloride benzyl alcohol solvate of claim 3 characterized by a PXRD diffractogram substantially similar to the PXRD diffractogram as depicted in FIG. 3 . 10. The vilazodone hydrochloride benzyl alcohol solvate of claim 3 characterized by a 1% KBr FTIR spectrum comprising peaks, in terms of cm −1 , at approximately 3237, 2584, 2210, 1678, 1605, 1575, 1367, and 1231.
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- C07D405/12Primary
linked by a chain containing hetero atoms as chain links · CPC title
Antidepressants · CPC title
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- What does patent US9382233B2 cover?
- Vilazodone hydrochloride benzyl alcohol solvates are provided as well as processes for the preparation thereof.
- Who is the assignee on this patent?
- Apotex Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D405/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 05 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).