Light absorption coefficient distribution estimation device, concentration measurement device, and method for controlling light absorption coefficient distribution estimation device

Patent metadata

Field	Value
Publication number	US-9380968-B2
Application number	US-201313935748-A
Country	US
Kind code	B2
Filing date	Jul 5, 2013
Priority date	Jul 9, 2012
Publication date	Jul 5, 2016
Grant date	Jul 5, 2016

Abstract

A light absorption coefficient distribution estimation device includes a detection section and a light absorption coefficient distribution estimation section. The detection section detects the received light intensity of scattered light from a subject at a plurality of light-receiving positions that differ in distance from an irradiation position at which measurement light is applied to the subject. The light absorption coefficient distribution estimation section estimates the light absorption coefficient distribution of the subject using the received light intensity, a propagation optical path length model that specifies a propagation optical path length on a basis of the distance, and a first model that specifies the received light intensity on a basis of the distance when absorption of light is at a predetermined value.

First claim

What is claimed is:

1. A light absorption coefficient distribution estimation device comprising:
a probe including a plurality of first light-receiving sections positioned at a first distance from an irradiation position at which measurement light is applied to a subject, a plurality of second light-receiving sections positioned at a second distance from the irradiation position, and a plurality of third light-receiving sections positioned at a third distance from the irradiation position; and
a control section configured to
calculate a first received light intensity by normalizing intensity of light received by the first light-receiving sections based on a number of the first light-receiving sections,
calculate a second received light intensity by normalizing intensity of light received by the second light-receiving sections based on a number of the second light-receiving sections,
calculate a third received light intensity by normalizing intensity of light received by the first light-receiving sections based on a number of the third light-receiving sections,
estimate a light absorption coefficient distribution of the subject using the first received light intensity, the second received light intensity, the third received light intensity, a propagation optical path length model that specifies a propagation optical path length on a basis of the first distance, the second distance and the third distance, and a first model that specifies the received light intensity on a basis of the first distance, the second distance and the third distance when absorption of light is at a predetermined value, and
correct the light absorption coefficient distribution using a second model that specifies a degree of variation in propagation optical path length of a photon on a basis of the first distance, the second distance and the third distance.

2. The light absorption coefficient distribution estimation device as defined in claim 1 , wherein
the first light-receiving sections, the second light-receiving sections and the third light-receiving sections are provided concentrically around an irradiation section that applies the measurement light.

3. The light absorption coefficient distribution estimation device as defined in claim 1 , wherein
the first light-receiving section, the second light-receiving section and the third light-receiving section are formed by a line sensor or an area sensor.

4. A concentration measurement device comprising:
the light absorption coefficient distribution estimation device as defined in claim 1 ; and
a concentration calculation section that calculates a concentration of a specific component in the subject using the light absorption coefficient distribution estimated by the light absorption coefficient distribution estimation section.

5. The light absorption coefficient distribution estimation device as defined in claim 1 , wherein
the first model is zero-absorption scattered light intensity model, and the predetermined value is zero.

6. The light absorption coefficient distribution estimation device as defined in claim 1 , wherein
the control section is configured to correct the light absorption coefficient distribution by obtaining the degree of variation at the first distance, the degree of variation at the second distance, and the degree of variation at the third distance by using the second model.

7. A light absorption coefficient distribution estimation method, executed by a computer including a processor, based on a received light intensity of light received by a probe that receives scattered light from a subject, to which measurement light is applied, the probe including a plurality of first light-receiving sections positioned at a first distance from an irradiation position at which the measurement light is applied to the subject, a plurality of second light-receiving sections positioned at a second distance from the irradiation position, and a plurality of third light-receiving sections positioned at a third distance from the irradiation position, the light absorption coefficient distribution estimation method comprising:
calculating, by the processor, a first received light intensity by normalizing intensity of light received by the first light-receiving sections based on a number of the first light-receiving sections;
calculating, by the processor, a second received light intensity by normalizing intensity of light received by the second light-receiving sections based on a number of the second light-receiving sections;
calculating, by the processor, a third received light intensity by normalizing intensity of light received by the first light-receiving sections based on a number of the third light-receiving sections;
estimating, by the processor, a light absorption coefficient distribution of the subject using the first received light intensity, the second received light intensity, the third received light intensity, a propagation optical path length model that specifies a propagation optical path length on a basis of the first distance, the second distance and the third distance, and a first model that specifies the received light intensity on a basis of the first distance, the second distance and the third distance when absorption of light is at a predetermined value; and
correcting, by the processor, the light absorption coefficient distribution using a second model that specifies a degree of variation in propagation optical path length of a photon on a basis of the first distance, the second distance and the third distance.

Assignees

• Seiko Epson Corp
• Univ Hokkaido Nat Univ Corp

Inventors

• Nishida Kazuhiro
• Shimizu Koichi
• Kato Yuji

Classifications

• A61B2562/046

  in a matrix array · CPC title

• A61B5/1455 Primary

  using optical sensors, e.g. spectral photometrical oximeters · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title